PMID- 32802835
OWN - NLM
STAT- MEDLINE
DCOM- 20210422
LR  - 20220416
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - Potential Molecular Mechanism of the NPPB Gene in Postischemic Heart Failure with 
      and without T2DM.
PG  - 2159460
LID - 10.1155/2020/2159460 [doi]
LID - 2159460
AB  - BACKGROUND: This study is aimed at investigating natriuretic peptide B (NPPB) 
      coexpression genes and their pathways involved in heart failure (HF) among 
      patients both with and without type 2 diabetes mellitus (T2DM). METHODS: The 
      microarray dataset GSE26887, containing 19 postischemic HF patients' peripheral 
      blood samples (7 with T2DM and 12 without T2DM), was examined to detect the genes 
      coexpressed with NPPB using the corr.test function in the R packet. Furthermore, 
      using online analytical tools, we determined the Kyoto Encyclopedia of Genes and 
      Genomes (KEGG) pathway enrichment analysis, Gene Ontology (GO) annotation, and 
      protein-protein interaction (PPI) network of the coexpression genes. The modules 
      and hub genes of the PPI network were then identified using the Cytoscape 
      software. RESULTS: In patients with T2DM, a total of 41 biological processes 
      (BP), 20 cellular components (CC), 13 molecular functions (MF), and 41 pathways 
      were identified. Furthermore, a total of 61 BPs, 16 CCs, 13 MFs, and 22 pathways 
      in patients without T2DM were identified. In both groups of patients, 17 BPs, 10 
      CCs, 6 MFs, and 13 pathways were enriched. We also identified 173 intersectional 
      coexpression genes (63 positively, 106 negatively, and 4 differently coexpressed 
      in patients with and without T2DM, respectively) in both types of patients, which 
      were enriched in 16 BPs, 8 CCs, 3 MFs, and 8 KEGG pathways. Moreover, the PPI 
      network (containing 237 edges and 170 nodes) with the top module significantly 
      enriched in 4 BPs (tricarboxylic acid metabolic process, citrate metabolic 
      process, tricarboxylic acid cycle, and aerobic respiration) and 3 pathways 
      (citrate cycle, malaria parasite metabolic pathway, and AGE-RAGE signaling 
      pathway in diabetic complications) was constructed. DECR1, BGN, TIMP1, VCAN, and 
      CTCF are the top hub genes. CONCLUSIONS: Our findings may elucidate the functions 
      and roles of the NPPB gene in patients with postischemic HF and facilitate HF 
      management.
CI  - Copyright (c) 2020 Yao-Zong Guan et al.
FAU - Guan, Yao-Zong
AU  - Guan YZ
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021 Guangxi, China.
FAU - Yin, Rui-Xing
AU  - Yin RX
AUID- ORCID: 0000-0001-7883-4310
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021 Guangxi, China.
AD  - Guangxi Key Laboratory Base of Precision Medicine in Cardio-Cerebrovascular 
      Disease Control and Prevention, Nanning, 530021 Guangxi, China.
AD  - Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases, Nanning, 
      530021 Guangxi, China.
FAU - Deng, Guo-Xiong
AU  - Deng GX
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021 Guangxi, China.
FAU - Zheng, Peng-Fei
AU  - Zheng PF
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021 Guangxi, China.
FAU - Liu, Chun-Xiao
AU  - Liu CX
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021 Guangxi, China.
FAU - Wei, Bi-Liu
AU  - Wei BL
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021 Guangxi, China.
LA  - eng
PT  - Journal Article
DEP - 20200803
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - *Databases, Nucleic Acid
MH  - Diabetes Mellitus, Type 2/*blood
MH  - *Gene Expression Regulation
MH  - Heart Failure/*blood/etiology
MH  - Humans
MH  - Myocardial Ischemia/*blood/complications
MH  - Natriuretic Peptide, Brain/*blood
PMC - PMC7424400
COIS- The authors declare that they have no competing interests.
EDAT- 2020/08/18 06:00
MHDA- 2021/04/23 06:00
PMCR- 2020/08/03
CRDT- 2020/08/18 06:00
PHST- 2020/05/10 00:00 [received]
PHST- 2020/06/24 00:00 [revised]
PHST- 2020/07/11 00:00 [accepted]
PHST- 2020/08/18 06:00 [entrez]
PHST- 2020/08/18 06:00 [pubmed]
PHST- 2021/04/23 06:00 [medline]
PHST- 2020/08/03 00:00 [pmc-release]
AID - 10.1155/2020/2159460 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Aug 3;2020:2159460. doi: 10.1155/2020/2159460. eCollection 
      2020.