PMID- 32802885
OWN - NLM
STAT- MEDLINE
DCOM- 20210422
LR  - 20210422
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - Protective Effects of MitoTEMPO on Nonalcoholic Fatty Liver Disease via 
      Regulating Myeloid-Derived Suppressor Cells and Inflammation in Mice.
PG  - 9329427
LID - 10.1155/2020/9329427 [doi]
LID - 9329427
AB  - MitoTEMPO, a mitochondrial antioxidant, has protective effects on liver-related 
      diseases. However, the role of MitoTEMPO on nonalcoholic fatty liver disease 
      (NAFLD) and its possible mechanisms are largely unknown. Here, we investigated 
      the effects of MitoTEMPO on NAFLD using high fat diet- (HFD-) induced obese mice 
      as animal models. MitoTEMPO was intraperitoneally injected into HFD mice. Liver 
      morphological changes were observed by H&E and Oil Red O staining, and the 
      frequency of MDSCs in peripheral blood was analyzed by flow cytometry. Moreover, 
      real-time quantitative PCR, western blot, and immunohistochemistry were conducted 
      to detect the mRNA and protein expressions in the liver tissues. The results 
      showed that the hepatic steatosis in liver tissues of HFD mice injected with 
      MitoTEMPO was significantly ameliorated. Additionally, MitoTEMPO reduced the 
      frequency of CD11b(+)Gr-1(+) MDSCs in peripheral circulation and decreased 
      Gr-1(+) cell accumulation in the livers. Further studies demonstrated that 
      MitoTEMPO administration suppressed the mRNA and protein expressions of 
      MDSC-associated proinflammatory mediators, such as monocyte chemoattractant 
      protein-1 (MCP-1), S100 calcium-binding protein A8 (S100A8), and S100 
      calcium-binding protein A9 (S100A9). Our results suggest that MitoTEMPO appears 
      to be a potential chemical compound affecting certain immune cells and further 
      ameliorates inflammation in obese-associated NAFLD.
CI  - Copyright (c) 2020 Jiayuan Wu et al.
FAU - Wu, Jiayuan
AU  - Wu J
AUID- ORCID: 0000-0002-5064-1944
AD  - The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
FAU - Zheng, Li
AU  - Zheng L
AUID- ORCID: 0000-0001-5360-4463
AD  - The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
FAU - Mo, Juanfen
AU  - Mo J
AUID- ORCID: 0000-0002-5858-1659
AD  - The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
FAU - Yao, Xiujuan
AU  - Yao X
AUID- ORCID: 0000-0001-5502-0779
AD  - Department of Pathology, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
FAU - Fan, Chenliang
AU  - Fan C
AUID- ORCID: 0000-0002-6918-0308
AD  - Clinical Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
FAU - Bao, Yi
AU  - Bao Y
AUID- ORCID: 0000-0001-7144-5849
AD  - The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
LA  - eng
PT  - Journal Article
DEP - 20200730
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (MitoTEMPO)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Piperidines)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation/*drug effects
MH  - Inflammation/metabolism/pathology/prevention & control
MH  - Liver/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Myeloid-Derived Suppressor Cells/*metabolism/pathology
MH  - *Non-alcoholic Fatty Liver Disease/metabolism/pathology/prevention & control
MH  - Organophosphorus Compounds/*pharmacology
MH  - Piperidines/*pharmacology
PMC - PMC7414374
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/08/18 06:00
MHDA- 2021/04/23 06:00
PMCR- 2020/07/30
CRDT- 2020/08/18 06:00
PHST- 2020/04/10 00:00 [received]
PHST- 2020/07/02 00:00 [revised]
PHST- 2020/07/08 00:00 [accepted]
PHST- 2020/08/18 06:00 [entrez]
PHST- 2020/08/18 06:00 [pubmed]
PHST- 2021/04/23 06:00 [medline]
PHST- 2020/07/30 00:00 [pmc-release]
AID - 10.1155/2020/9329427 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Jul 30;2020:9329427. doi: 10.1155/2020/9329427. eCollection 
      2020.