PMID- 32804289
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1432-1068 (Electronic)
IS  - 1633-8065 (Linking)
VI  - 31
IP  - 2
DP  - 2021 Feb
TI  - Allogeneic umbilical cord-derived mesenchymal stem cells for treating 
      critical-sized bone defects: a translational study.
PG  - 265-273
LID - 10.1007/s00590-020-02765-5 [doi]
AB  - INTRODUCTION: The current 'gold-standard' treatment of critical-sized bone 
      defects (CSBDs) is autografts; however, they have drawbacks including lack of 
      massive bone source donor site morbidity, incomplete remodeling, and the risk of 
      infection. One potential treatment for treating CSBDs is bone marrow-derived 
      mesenchymal stem cells (BM-MSCs). Previously, there were no studies regarding the 
      use of human umbilical cord-mesenchymal stem cells (hUC-MSCs) for treating BDs. 
      We aim to investigate the use of allogeneic hUC-MSCs for treating CSBDs. METHOD: 
      We included subjects who were diagnosed with non-union fracture with CSBDs who 
      agreed to undergo hUC-MSCs implantation. All patients were given allogeneic 
      hUC-MSCs. All MSCs were obtained and cultured using the multiple-harvest explant 
      method. Subjects were evaluated functionally using the Lower Extremity Functional 
      Scale (LEFS) and radiologically by volume defect reduction. RESULT: A total of 
      seven (3 male, 4 female) subjects were recruited for this study. The subjects age 
      ranged from 14 to 62 years. All seven subjects had increased LEFS during the end 
      of the follow-up period, indicating improved functional ability. The follow-up 
      period ranged from 12 to 36 months. One subject had wound dehiscence and 
      infection, and two subjects developed partial union. CONCLUSION: Umbilical cord 
      mesenchymal stem cells are a potential new treatment for CSBDs. Additional 
      studies with larger samples and control groups are required to further 
      investigate the safety and efficacy of umbilical cord-derived mesenchymal stem 
      cells for treating CSBDs.
FAU - Dilogo, Ismail Hadisoebroto
AU  - Dilogo IH
AUID- ORCID: 0000-0002-6202-0918
AD  - Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General 
      Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. 
      ismailortho@gmail.com.
AD  - Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central 
      Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, 
      Jl. Diponegoro 71, Jakarta Pusat, Indonesia. ismailortho@gmail.com.
AD  - Stem Cell and Tissue Engineering Research Center, IMERI, Faculty of Medicine, 
      Universitas Indonesia, Jakarta, Indonesia. ismailortho@gmail.com.
FAU - Rahmatika, Dina
AU  - Rahmatika D
AD  - Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central 
      Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, 
      Jl. Diponegoro 71, Jakarta Pusat, Indonesia.
FAU - Pawitan, Jeanne Adiwinata
AU  - Pawitan JA
AD  - Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central 
      Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, 
      Jl. Diponegoro 71, Jakarta Pusat, Indonesia.
AD  - Department Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba 6, 
      Jakarta, Indonesia.
AD  - Stem Cell and Tissue Engineering Research Center, IMERI, Faculty of Medicine, 
      Universitas Indonesia, Jakarta, Indonesia.
FAU - Liem, Isabella Kurnia
AU  - Liem IK
AD  - Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central 
      Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, 
      Jl. Diponegoro 71, Jakarta Pusat, Indonesia.
AD  - Stem Cell and Tissue Engineering Research Center, IMERI, Faculty of Medicine, 
      Universitas Indonesia, Jakarta, Indonesia.
AD  - Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba 6, 
      Jakarta, Indonesia.
FAU - Kurniawati, Tri
AU  - Kurniawati T
AD  - Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central 
      Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, 
      Jl. Diponegoro 71, Jakarta Pusat, Indonesia.
AD  - Stem Cell and Tissue Engineering Research Center, IMERI, Faculty of Medicine, 
      Universitas Indonesia, Jakarta, Indonesia.
FAU - Kispa, Tera
AU  - Kispa T
AD  - Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central 
      Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, 
      Jl. Diponegoro 71, Jakarta Pusat, Indonesia.
FAU - Mujadid, Fajar
AU  - Mujadid F
AD  - Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central 
      Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, 
      Jl. Diponegoro 71, Jakarta Pusat, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20200817
PL  - France
TA  - Eur J Orthop Surg Traumatol
JT  - European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
JID - 9518037
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Female
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - *Mesenchymal Stem Cells
MH  - Middle Aged
MH  - Transplantation, Autologous
MH  - Umbilical Cord
MH  - Young Adult
OTO - NOTNLM
OT  - Critical-sized bone defect
OT  - Mesenchymal stem cells
OT  - Umbilical cord
EDAT- 2020/08/18 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/08/18 06:00
PHST- 2020/07/16 00:00 [received]
PHST- 2020/08/05 00:00 [accepted]
PHST- 2020/08/18 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/08/18 06:00 [entrez]
AID - 10.1007/s00590-020-02765-5 [pii]
AID - 10.1007/s00590-020-02765-5 [doi]
PST - ppublish
SO  - Eur J Orthop Surg Traumatol. 2021 Feb;31(2):265-273. doi: 
      10.1007/s00590-020-02765-5. Epub 2020 Aug 17.