PMID- 32804939
OWN - NLM
STAT- MEDLINE
DCOM- 20201007
LR  - 20201007
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 8
DP  - 2020
TI  - Circulating human anti nucleolus antibody (ANCAb) and biochemical parameters in 
      type 2 diabetic patients with and without complications.
PG  - e0237109
LID - 10.1371/journal.pone.0237109 [doi]
LID - e0237109
AB  - INTRODUCTION: There is no evidence on the role of Human Anti Nucleolus Antibody 
      (ANCAb) in type 2 diabetes mellitus (T2DM). We compared prevalence and 
      concentration of ANCAb between age and a gender-matched sample of T2DM with and 
      without diabetes-related complications. METHODS: In this study, the reaction to 
      ANCAb was compared quantitatively between 38 T2DM patients complicated with 
      microvascular conditions and 43 T2DM without complications as controls. RESULTS: 
      The patients in complicated and non-complicated groups were comparable in 
      diabetes duration (9.0 vs. 5.0 years; P = 0.065), respectively. The study found 
      that 27 cases (71.1%) of the complicated group reacted to ANCAb test compared to 
      25 (58.1%) in non-complicated patients (P = 0.226; 3.53 vs. 2.72 ng/mL; P = 
      0.413). The reaction response to ANCAb in patients with neuropathy and 
      cardiovascular complications was 80.0%, 76.2% in patients with neuropathy 
      compared to 58.1% in the control group (P = 0.398). The reaction response to 
      ANCAb in patients with mono-complication was 72.7% compared 68.8% in patients 
      with multi-complication (P = 0.466). Similarly, 76.2% of patients with T2DM and 
      complicated with neuropathy (n = 21 patients) reacted to ANCAb compared to 58.1% 
      in control patients with (P = 0.158). CONCLUSIONS: Reaction to ANCAb was not 
      statistically different between the T2DM patients with and without complications.
FAU - Rajab, Heevi Ameen
AU  - Rajab HA
AD  - Medical Chemistry Department, College of Medicine, University of Duhok-Iraq, 
      Duhok, Iraq.
FAU - Hassan, Alan Bapeer
AU  - Hassan AB
AD  - Basic Sciences Unit, College of Nursing, University of Duhok-Iraq, Duhok, Iraq.
FAU - Hassan, Israa Issa
AU  - Hassan II
AD  - Basic Sciences Unit, College of Nursing, University of Duhok-Iraq, Duhok, Iraq.
FAU - Abdulah, Deldar Morad
AU  - Abdulah DM
AUID- ORCID: 0000-0002-8986-5793
AD  - Community Health Unit, College of Nursing, University of Duhok-Iraq, Duhok, Iraq.
FAU - Saadi, Farsat Saeed
AU  - Saadi FS
AD  - Head of CPD Department, Duhok General Directorate of Health-Iraq, Duhok, Iraq.
LA  - eng
PT  - Journal Article
DEP - 20200817
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*blood/immunology
MH  - Biomarkers/blood
MH  - Cell Nucleolus/*immunology
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Diabetic Angiopathies/*blood
MH  - Diabetic Neuropathies/*blood
MH  - Female
MH  - Humans
MH  - Middle Aged
PMC - PMC7430723
COIS- The authors do not declare any conflict of interest.
EDAT- 2020/08/18 06:00
MHDA- 2020/10/08 06:00
PMCR- 2020/08/17
CRDT- 2020/08/18 06:00
PHST- 2020/03/30 00:00 [received]
PHST- 2020/07/20 00:00 [accepted]
PHST- 2020/08/18 06:00 [entrez]
PHST- 2020/08/18 06:00 [pubmed]
PHST- 2020/10/08 06:00 [medline]
PHST- 2020/08/17 00:00 [pmc-release]
AID - PONE-D-20-08208 [pii]
AID - 10.1371/journal.pone.0237109 [doi]
PST - epublish
SO  - PLoS One. 2020 Aug 17;15(8):e0237109. doi: 10.1371/journal.pone.0237109. 
      eCollection 2020.