PMID- 3280601
OWN - NLM
STAT- MEDLINE
DCOM- 19880512
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 81
IP  - 4
DP  - 1988 Apr
TI  - Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and 
      insulin resistance.
PG  - 1137-45
AB  - To study the mechanism of the diabetogenic action of ethanol, ethanol (0.75 g/kg 
      over 30 min) and then glucose (0.5 g/kg over 5 min) were infused intravenously 
      into six normal males. During the 4-h study, 21.8 +/- 2.1 g of ethanol was 
      metabolized and oxidized to CO2 and H2O. Ethanol decreased total body fat 
      oxidation by 79% and protein oxidation by 39%, and almost completely abolished 
      the 249% rise in carbohydrate (CHO) oxidation seen in controls after glucose 
      infusion. Ethanol decreased the basal rate of glucose appearance (GRa) by 30% and 
      the basal rate of glucose disappearance (GRd) by 38%, potentiated 
      glucose-stimulated insulin release by 54%, and had no effect on glucose 
      tolerance. In hyperinsulinemic-euglycemic clamp studies, ethanol caused a 36% 
      decrease in glucose disposal. We conclude that ethanol was a preferred fuel 
      preventing fat, and to lesser degrees, CHO and protein, from being oxidized. It 
      also caused acute insulin resistance which was compensated for by hypersecretion 
      of insulin.
FAU - Shelmet, J J
AU  - Shelmet JJ
AD  - Department of Medicine, Temple University Hospital, Philadelphia, Pennsylvania 
      19140.
FAU - Reichard, G A
AU  - Reichard GA
FAU - Skutches, C L
AU  - Skutches CL
FAU - Hoeldtke, R D
AU  - Hoeldtke RD
FAU - Owen, O E
AU  - Owen OE
FAU - Boden, G
AU  - Boden G
LA  - eng
GR  - 5T32 AM-07162/AM/NIADDK NIH HHS/United States
GR  - AM-34548/AM/NIADDK NIH HHS/United States
GR  - AM-36192/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Acetates)
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Proteins)
RN  - 3K9958V90M (Ethanol)
RN  - EC 2.7.10.1 (Receptor, Insulin)
SB  - IM
MH  - Acetates/blood
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Calorimetry
MH  - *Carbohydrate Metabolism
MH  - Ethanol/*pharmacology
MH  - Fatty Acids, Nonesterified/blood
MH  - Humans
MH  - Insulin/metabolism
MH  - *Insulin Resistance
MH  - *Lipid Metabolism
MH  - Liver/metabolism
MH  - Male
MH  - Oxidation-Reduction
MH  - Proteins/*metabolism
MH  - Receptor, Insulin/metabolism
PMC - PMC329642
EDAT- 1988/04/01 00:00
MHDA- 1988/04/01 00:01
PMCR- 1988/04/01
CRDT- 1988/04/01 00:00
PHST- 1988/04/01 00:00 [pubmed]
PHST- 1988/04/01 00:01 [medline]
PHST- 1988/04/01 00:00 [entrez]
PHST- 1988/04/01 00:00 [pmc-release]
AID - 10.1172/JCI113428 [doi]
PST - ppublish
SO  - J Clin Invest. 1988 Apr;81(4):1137-45. doi: 10.1172/JCI113428.