PMID- 32806275
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 116
DP  - 2020 Nov
TI  - Influence of surface oxygen clusters upon molecular stacking of paclitaxel over 
      graphene oxide sheets.
PG  - 111232
LID - S0928-4931(20)31563-0 [pii]
LID - 10.1016/j.msec.2020.111232 [doi]
AB  - Aqueous dispersibility of graphene oxide (GO) sheets can be improved through 
      enrichment of oxygen content (oxidation). However, the resulting 'oxygen 
      clusters' are accompanied with numerous point defects, depletive to pi-pi stacking 
      behavior of sheets. In this work, we have investigated the properties of sheets 
      oxidized with 2, 4, 6, 8, 10 and 12 weight equivalents of KMnO(4). Sheets were 
      characterized by spectroscopic, X-ray diffraction (XRD) and electron microscopic 
      techniques. Paclitaxel (PLX) was used as a model drug to analyze the changes in 
      the loading efficiency at different levels of oxidation. Density of oxygen 
      clusters increased as we shifted across increasing proportion of KMnO(4). This 
      was accompanied with increased inter-layer spacing, disruption of pure graphitic 
      domains and changes in hybridization of carbon atoms (sp(2) to sp(3)). However, 
      these defects exhibited the tendency of saturation at a finite proportion of 
      KMnO(4). Oxygen groups negatively affected the loading efficiency of sheets for 
      PLX. Improvement in the loading efficiency of reduced GO (rGO) sheets clarified 
      the predominant role of pi-pi interactions at the surface. Our study reveals that 
      high oxidation may offset the loading potential of highly aqueous dispersible GO 
      sheets. Therefore, the extent of oxidation must be tuned taking into account the 
      availability of H-bond forming groups in the drug molecule.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Patil, Rahul
AU  - Patil R
AD  - UKA Tarsadia University, Maliba Pharmacy College, Gopal-Vidyanagar Campus, Surat 
      394350, India.
FAU - Patel, Harsh
AU  - Patel H
AD  - UKA Tarsadia University, Maliba Pharmacy College, Gopal-Vidyanagar Campus, Surat 
      394350, India.
FAU - Pillai, Sharad B
AU  - Pillai SB
AD  - Department of Physics, Faculty of Science, The Maharaja Sayajirao University of 
      Baroda, Vadodara 390002, India.
FAU - Jha, Prafulla K
AU  - Jha PK
AD  - Department of Physics, Faculty of Science, The Maharaja Sayajirao University of 
      Baroda, Vadodara 390002, India.
FAU - Bahadur, Pratap
AU  - Bahadur P
AD  - Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, 
      India.
FAU - Tiwari, Sanjay
AU  - Tiwari S
AD  - UKA Tarsadia University, Maliba Pharmacy College, Gopal-Vidyanagar Campus, Surat 
      394350, India. Electronic address: tiwarisanju@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20200623
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Oxides)
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
RN  - P88XT4IS4D (Paclitaxel)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Graphite
MH  - Oxides
MH  - Oxygen
MH  - *Paclitaxel
OTO - NOTNLM
OT  - Graphene oxide
OT  - Nanosheets
OT  - Oxidative exfoliation
OT  - Oxygen clusters, Paclitaxel, pi-pi stacking
COIS- Declaration of competing interest All authors have read and approved this 
      submission. We declare no conflict of interest. This declaration is being made by 
      the corresponding author on behalf of co-authors.
EDAT- 2020/08/19 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/08/19 06:00
PHST- 2020/04/08 00:00 [received]
PHST- 2020/06/10 00:00 [revised]
PHST- 2020/06/21 00:00 [accepted]
PHST- 2020/08/19 06:00 [entrez]
PHST- 2020/08/19 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
AID - S0928-4931(20)31563-0 [pii]
AID - 10.1016/j.msec.2020.111232 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111232. doi: 
      10.1016/j.msec.2020.111232. Epub 2020 Jun 23.