PMID- 3280675
OWN - NLM
STAT- MEDLINE
DCOM- 19880422
LR  - 20131121
IS  - 0263-6352 (Print)
IS  - 0263-6352 (Linking)
VI  - 6
IP  - 2
DP  - 1988 Feb
TI  - Medial prefrontal cortical lesions and baroreceptor heart rate reflex sensitivity 
      in the spontaneously hypertensive rat.
PG  - 123-7
AB  - Previous investigations have shown that an excitotoxic lesion of the medial 
      prefrontal cortex (MPFC) in normotensive Sprague-Dawley rats results in a 
      reduction in the sensitivity of the baroreceptor heart rate reflex. The aim of 
      this study was to examine the importance of the MPFC in regulation of the heart 
      rate reflex in conscious, unrestrained spontaneously hypertensive rats (SHR). The 
      MPFC was lesioned by bilateral microinfusions of the excitotoxin 
      N-methyl-D-aspartic acid (NMDA). Baroreceptor heart rate reflex testing was 
      performed by measuring reflex heart rate changes in response to blood pressure 
      alterations induced by nitroprusside and phenylephrine with subsequent 
      computerized sigmoidal curve-fitting of the data. Lesion of the MPFC did not 
      significantly alter resting, systolic and diastolic blood pressure, heart rate or 
      baro-reflex parameters (gain, thresholds, range or plateaus). These observations 
      suggest that the putative descending facilitatory influence from the MPFC to 
      brainstem areas, involved in baroreceptor reflex regulation observed in 
      normotensive rats, may be defective in SHR.
FAU - Verberne, A J
AU  - Verberne AJ
AD  - University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, 
      Victoria, Australia.
FAU - Lewis, S J
AU  - Lewis SJ
FAU - Jarrott, B
AU  - Jarrott B
FAU - Louis, W J
AU  - Louis WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Hypertens
JT  - Journal of hypertension
JID - 8306882
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/pharmacology
MH  - Cerebral Cortex/drug effects/*physiology
MH  - *Heart Rate
MH  - Hypertension/*physiopathology
MH  - Male
MH  - N-Methylaspartate
MH  - Pressoreceptors/*physiology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Reflex/*physiology
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
PST - ppublish
SO  - J Hypertens. 1988 Feb;6(2):123-7.