PMID- 32806878 OWN - NLM STAT- MEDLINE DCOM- 20210923 LR - 20211207 IS - 2005-6648 (Electronic) IS - 1226-3303 (Print) IS - 1226-3303 (Linking) VI - 36 IP - 5 DP - 2021 Sep TI - Evaluation of body composition using computed tomography in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis. PG - 1221-1232 LID - 10.3904/kjim.2020.064 [doi] AB - BACKGROUND/AIMS: Measures of body composition, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and skeletal muscle area (SMA), are considered important prognostic factors in chronic diseases. The association of these measures with auto-inflammatory disorders, such as anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), remains unclear. We investigated the clinical significance of VAT, SAT, and SMA in patients with AAV. METHODS: Patients with AAV subjected to chest computed tomography (CT), abdominal CT, or positron emission tomography-CT on diagnosis of AAV were evaluated. Quantitative assessment of VAT, SAT, and SMA was performed at the third lumbar vertebral level and computed by summing the pixel attenuation for tissue-specific Hounsfield units in the corresponding region. Associations of VAT, SAT, and SMA with clinical and laboratory data and clinical outcome measures were evaluated. RESULTS: Of the 117 patients, 61 (52.1%) were classified as having microscopic polyangiitis, 28 (23.9%) as granulomatosis with polyangiitis, and 28 (23.9%) as eosinophilic granulomatosis with polyangiitis. VAT significantly correlated with age, weight, body mass index (BMI), and Birmingham Vasculitis Activity Score, whereas SAT correlated with weight, BMI, and creatinine levels. A significant association was found between SMA and age, height, weight, BMI, and the Five-Factor Score. Cox proportional hazards analysis showed that creatinine levels (odds ratio [OR], 1.346; 95% confidence interval [CI], 1.034 to 1.753; p = 0.027) and high VAT (OR, 7.137; 95% CI, 1.343-37.946; p = 0.021) were independently associated with all-cause mortality during follow-up. CONCLUSION: Evaluation of VAT using CT is useful for estimating disease activity and all-cause mortality in patients with AAV. FAU - Ahn, Sung Soo AU - Ahn SS AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. FAU - Yoo, Byung-Woo AU - Yoo BW AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. FAU - Kwon, Hyeok Chan AU - Kwon HC AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. FAU - Yoo, Juyoung AU - Yoo J AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. FAU - Jung, Seung Min AU - Jung SM AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. FAU - Song, Jason Jungsik AU - Song JJ AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. AD - Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea. FAU - Park, Yong-Beom AU - Park YB AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. AD - Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea. FAU - Lee, Sang-Won AU - Lee SW AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. AD - Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea. LA - eng GR - 2017R1D1A1B03029050/National Research Foundation of Korea/ GR - Ministry of Education/ GR - HI14C1324/Korea Health Industry Development Institute/Republic of Korea GR - Ministry of Health and Welfare/ PT - Journal Article DEP - 20200818 PL - Korea (South) TA - Korean J Intern Med JT - The Korean journal of internal medicine JID - 8712418 SB - IM MH - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnostic imaging MH - Body Composition MH - Body Mass Index MH - *Churg-Strauss Syndrome MH - *Granulomatosis with Polyangiitis MH - Humans MH - Intra-Abdominal Fat/diagnostic imaging MH - Tomography, X-Ray Computed PMC - PMC8435509 OTO - NOTNLM OT - Anti-neutrophil cytoplasmic antibody-associated vasculitis OT - Body composition OT - Computed tomography OT - Prognosis OT - Visceral adipose tissue COIS- No potential conflict of interest relevant to this article was reported. EDAT- 2020/08/19 06:00 MHDA- 2021/09/24 06:00 PMCR- 2021/09/01 CRDT- 2020/08/19 06:00 PHST- 2020/02/20 00:00 [received] PHST- 2020/04/28 00:00 [accepted] PHST- 2020/08/19 06:00 [pubmed] PHST- 2021/09/24 06:00 [medline] PHST- 2020/08/19 06:00 [entrez] PHST- 2021/09/01 00:00 [pmc-release] AID - kjim.2020.064 [pii] AID - kjim-2020-064 [pii] AID - 10.3904/kjim.2020.064 [doi] PST - ppublish SO - Korean J Intern Med. 2021 Sep;36(5):1221-1232. doi: 10.3904/kjim.2020.064. Epub 2020 Aug 18.