PMID- 32806924
OWN - NLM
STAT- MEDLINE
DCOM- 20210721
LR  - 20220402
IS  - 1552-4175 (Electronic)
IS  - 1099-8004 (Print)
IS  - 1099-8004 (Linking)
VI  - 23
IP  - 2
DP  - 2021 Apr
TI  - Sex Hormones, BDNF, Leptin, and TGF-beta1 in Females With IBS: A Pilot 
      Investigation.
PG  - 231-237
LID - 10.1177/1099800420948589 [doi]
AB  - BACKGROUND: Irritable bowel syndrome (IBS) is a chronic gastrointestinal 
      condition predominantly affecting the female sex, and is characterized by 
      brain-gut axis dysregulation. Relevance of hormones along the 
      hypothalamic-pituitary gonadal axis and hypothalamic-pituitary adrenal axis to 
      IBS symptomatology remain unclear, as does the significance of other modulators 
      including brain derived neurotrophic factor (BDNF), leptin, and transforming 
      growth factor betaeta 1 (TGF-beta1). METHODS: Females with IBS were compared with 
      female healthy controls (HC) on age, race, hormonal contraceptive use, body mass 
      index, adrenocorticotropic hormone, cortisol, estradiol, follicular stimulating 
      hormone, luteinizing hormone, progesterone, total cholesterol, Center for 
      Epidemiological Studies Depression Scale (CES-D) and Perceived Stress Scale 
      (PSS). BDNF, leptin, and TGF-beta1 were quantified using enzyme-linked immunosorbent 
      assay. Descriptive statistics, non-parametric techniques, and regression analyses 
      were performed. RESULTS: Participants with IBS (n = 12) displayed higher 
      estradiol (p = .027) than did HC (n = 21). Direction of associations among study 
      variables often differed between groups: BDNF and progesterone in HC (r(s) = 
      .623) and in IBS (r(s) = -.723). The relationship between log (CES-D) and log 
      (estradiol) varied by IBS status (interaction term p = 0.019). DISCUSSION: 
      Elevated estradiol in participants with IBS, and differential patterns of 
      biological and psychological indices between groups, encourages further inquiry 
      on the relevance of sex hormones, BDNF, leptin, and TGF-beta1 to symptoms of IBS. 
      Future research endeavors should conduct longitudinal quantification of sex 
      hormones with subjective symptom assessment to facilitate insight on the 
      pathophysiology and female sex bias in IBS.
FAU - Weaver, Kristen R
AU  - Weaver KR
AUID- ORCID: 0000-0002-8757-8758
AD  - 12265University of Maryland, School of Nursing, Baltimore, MD, USA.
AD  - National Institute of Nursing Research, National Institutes of Health, Bethesda, 
      MD, USA.
FAU - Boulineaux, Christina M
AU  - Boulineaux CM
AD  - 1811Harvard Medical School, Boston, MA, USA.
FAU - Robinson, Jeffrey M
AU  - Robinson JM
AD  - Translational Life Science Technology Program, 205813UMBC at The Universities of 
      Shady Grove, Rockville, MD, USA.
FAU - Butler, Kierra
AU  - Butler K
AD  - National Institute of Nursing Research, National Institutes of Health, Bethesda, 
      MD, USA.
FAU - Heitkemper, Margaret M
AU  - Heitkemper MM
AD  - Department of Biobehavioral Nursing and Health Informatics, 7284University of 
      Washington, School of Nursing, Seattle, WA, USA.
FAU - Henderson, Wendy A
AU  - Henderson WA
AUID- ORCID: 0000-0003-3924-7118
AD  - Center of Nursing Scholarship and Innovation, 7712University of Connecticut, 
      School of Nursing, Storrs, CT, USA.
LA  - eng
GR  - T32 NS070201/NS/NINDS NIH HHS/United States
GR  - UL1 TR001079/TR/NCATS NIH HHS/United States
GR  - ZIA NR000018/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200818
PL  - United States
TA  - Biol Res Nurs
JT  - Biological research for nursing
JID - 9815758
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Leptin)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depression/blood/psychology
MH  - Female
MH  - Gonadal Steroid Hormones/*blood
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Irritable Bowel Syndrome/*blood/psychology
MH  - Leptin/*blood
MH  - Pilot Projects
MH  - Transforming Growth Factor beta1/*blood
PMC - PMC8264858
OTO - NOTNLM
OT  - BDNF
OT  - IBS
OT  - TGF-beta1
OT  - irritable bowel syndrome
OT  - leptin
OT  - sex hormones
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2020/08/19 06:00
MHDA- 2021/07/22 06:00
PMCR- 2022/04/01
CRDT- 2020/08/19 06:00
PHST- 2020/08/19 06:00 [pubmed]
PHST- 2021/07/22 06:00 [medline]
PHST- 2020/08/19 06:00 [entrez]
PHST- 2022/04/01 00:00 [pmc-release]
AID - 10.1177_1099800420948589 [pii]
AID - 10.1177/1099800420948589 [doi]
PST - ppublish
SO  - Biol Res Nurs. 2021 Apr;23(2):231-237. doi: 10.1177/1099800420948589. Epub 2020 
      Aug 18.