PMID- 32807188 OWN - NLM STAT- MEDLINE DCOM- 20201124 LR - 20201124 IS - 1476-069X (Electronic) IS - 1476-069X (Linking) VI - 19 IP - 1 DP - 2020 Aug 17 TI - Concentrations of perfluoroalkyl and polyfluoroalkyl substances and blood glucose in pregnant women. PG - 88 LID - 10.1186/s12940-020-00640-8 [doi] LID - 88 AB - BACKGROUND: Evidence on the association between exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) and blood glucose concentrations in pregnant women is inconsistent. This study aimed to examine the association between PFAS exposure and the concentrations of fasting plasma glucose (FPG) and one-hour plasma glucose (1 h-PG) after a 50-g oral glucose tolerance test in pregnant women. METHODS: The study was based on the Shanghai-Minhang Birth Cohort, in which 1292 pregnant women were recruited. Among them, 981 women provided blood samples (at 12-16 gestational weeks) for PFAS measurement. FPG data collected from 856 women at 12-20 GW and 1 h-PG data collected from 705 women at 20-28 GW were obtained through medical records from the routine prenatal care system. High FPG or 1 h-PG was defined as >/=90th percentile of FPG or 1 h-PG. The analysis of eight PFASs was conducted in this study: perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUdA), perfluorododecanoic acid (PFDoA), and perfluorotridecanoic acid (PFTrDA). The odds ratios (ORs) and associated 95% confidence intervals (CIs) were estimated to determine the associations of each PFAS compound with high FPG and 1 h-PG from a logistic regression model. RESULTS: After adjustment for potential confounders, most PFASs were positively associated with high 1 h-PG concentrations. The OR for high 1 h-PG concentrations was 1.87 (95% CI: 1.15-3.05) with a one log unit increase of PFOS; similar associations were observed for PFNA (OR: 2.15, 95% CI: 1.24-3.74), PFDA (OR: 1.61, 95% CI: 1.10-2.44), PFUdA (OR: 1.71, 95% CI: 1.12-2.62), and PFDoA (OR: 1.34, 95% CI: 1.00-1.81). When the PFAS concentrations were categorized into three groups by tertiles, the highest tertiles of PFOS, PFOA, PFNA, PFDA, PFDoA, and PFTrDA had a statistically significant increase in the risk of high 1 h-PG concentrations compared with the lowest tertiles. No statistically significant association was observed between PFAS exposure and high FPG. CONCLUSION: PFAS exposure was associated with an increased risk of high 1 h-PG among pregnant women, but no such association was observed for FPG. FAU - Ren, Yanfeng AU - Ren Y AD - Department of Health Statistics, School of Public Health, Weifang Medical University, Weifang, Shandong, China. FAU - Jin, Longmei AU - Jin L AD - Minhang District Maternal and Child Health Hospital, Shanghai, China. FAU - Yang, Fen AU - Yang F AD - Department of Global Public Health, Karolinska Institute, Stockholm, Sweden. FAU - Liang, Hong AU - Liang H AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. FAU - Zhang, Zhaofeng AU - Zhang Z AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. FAU - Du, Jing AU - Du J AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. FAU - Song, Xiuxia AU - Song X AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. FAU - Miao, Maohua AU - Miao M AUID- ORCID: 0000-0003-1509-2035 AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. miaomaohua@163.com. FAU - Yuan, Wei AU - Yuan W AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. LA - eng GR - 2016YFC1000505/National key research and development program [grant numbers/International GR - 2018YFC1002801/National key research and development program [grant numbers/International GR - 201840184/Shanghai Municipal Commission of Health and Family Planning/International GR - CX2017-06/Innovation-oriented Science and Technology Grant from NHC Key Laboratory of Reproduction Regulation/International GR - 2018WS060/Shandong Medical and Health Science and Technology Development Project/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200817 PL - England TA - Environ Health JT - Environmental health : a global access science source JID - 101147645 RN - 0 (Blood Glucose) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) SB - IM MH - Adult MH - Blood Glucose/*analysis MH - China MH - Cohort Studies MH - Environmental Exposure/*analysis MH - Environmental Monitoring MH - Environmental Pollutants/*blood MH - Female MH - Fluorocarbons/*blood MH - Humans MH - Pregnancy MH - Young Adult PMC - PMC7433207 OTO - NOTNLM OT - Cohort study OT - Perfluoroalkyl and polyfluoroalkyl substances OT - Plasma glucose OT - Pregnancy COIS- The authors declare they have no actual or potential competing financial interests. EDAT- 2020/08/19 06:00 MHDA- 2020/11/25 06:00 PMCR- 2020/08/17 CRDT- 2020/08/19 06:00 PHST- 2020/05/18 00:00 [received] PHST- 2020/08/06 00:00 [accepted] PHST- 2020/08/19 06:00 [entrez] PHST- 2020/08/19 06:00 [pubmed] PHST- 2020/11/25 06:00 [medline] PHST- 2020/08/17 00:00 [pmc-release] AID - 10.1186/s12940-020-00640-8 [pii] AID - 640 [pii] AID - 10.1186/s12940-020-00640-8 [doi] PST - epublish SO - Environ Health. 2020 Aug 17;19(1):88. doi: 10.1186/s12940-020-00640-8.