PMID- 32807868
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20201027
LR  - 20210817
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Aug 17
TI  - Effect of image quality fluctuations on the repeatability of thickness 
      measurements in swept-source optical coherence tomography.
PG  - 13897
LID - 10.1038/s41598-020-70852-y [doi]
LID - 13897
AB  - This study investigated the effect of image quality fluctuations on the 
      repeatability of thickness measurements of the peripapillary retinal nerve fibre 
      (PP-RNFL) and ganglion cell-inner plexiform (GC-IPL) layers using swept-source 
      optical coherence tomography (SS-OCT). Three consecutive OCT scans each were 
      performed on 56 healthy subject. Finally, 168 SS-OCT results were analysed. Based 
      on the tertile values of the mean absolute difference of image quality score, all 
      subjects were divided into the following three groups-low-(LIQD), 
      moderate-(MIQD), and high-(HIQD) image quality score difference groups. A linear 
      mixed model and intraclass correlation coefficients (ICCs) were used for 
      analyses. Despite high ICC values (> 0.9), several sectors showed significant 
      differences in the ICC values in intergroup comparisons. For LIQD-HIQD and 
      MIQD-HIQD, most PP-RNFL sectors showed significant differences. For GC-IPL 
      sectors, the LIQD-HIQD comparison showed significant differences in the 
      temporosuperior (p = 0.012), inferior (p < .001), and temporoinferior (p = 0.042) 
      sectors. Significant differences existed in the average GC-IPL (p = 0.009), 
      nasoinferior (p = 0.035), and inferior GC-IPL sectors (p < .001) for MIQD-HIQD 
      comparison. With higher image quality fluctuations, the repeatability of SS-OCT 
      decreased in several sectors, which are considered clinically relevant in 
      evaluating glaucoma status. Therefore, maintaining high-quality image status is 
      essential to enhance the reliability of SS-OCT.
FAU - Yang, Heon
AU  - Yang H
AD  - Kong Eye Center, Seoul, Republic of Korea.
FAU - Lee, Hye Sun
AU  - Lee HS
AD  - Biostatistics Collaboration Unit, Department of Research Affairs, Yonsei 
      University College of Medicine, Seoul, Republic of Korea.
FAU - Bae, Hyoung Won
AU  - Bae HW
AD  - Department of Ophthalmology, Institute of Vision Research, Severance Hospital, 
      Yonsei University College of Medicine, Seoul, Republic of Korea.
FAU - Seong, Gong Je
AU  - Seong GJ
AD  - Department of Ophthalmology, Institute of Vision Research, Severance Hospital, 
      Yonsei University College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Chan Yun
AU  - Kim CY
AD  - Department of Ophthalmology, Institute of Vision Research, Severance Hospital, 
      Yonsei University College of Medicine, Seoul, Republic of Korea.
FAU - Lee, Sang Yeop
AU  - Lee SY
AD  - Department of Ophthalmology, Institute of Vision Research, Severance Hospital, 
      Yonsei University College of Medicine, Seoul, Republic of Korea. yeopy@yuhs.ac.
AD  - Department of Ophthalmology, Yongin Severance Hospital, Yonsei University College 
      of Medicine, Yongin, Gyeonggi-do, Republic of Korea. yeopy@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20200817
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
PMC - PMC7431557
COIS- The authors declare no competing interests.
EDAT- 2020/08/19 06:00
MHDA- 2020/08/19 06:01
PMCR- 2020/08/17
CRDT- 2020/08/19 06:00
PHST- 2020/02/17 00:00 [received]
PHST- 2020/07/23 00:00 [accepted]
PHST- 2020/08/19 06:00 [entrez]
PHST- 2020/08/19 06:00 [pubmed]
PHST- 2020/08/19 06:01 [medline]
PHST- 2020/08/17 00:00 [pmc-release]
AID - 10.1038/s41598-020-70852-y [pii]
AID - 70852 [pii]
AID - 10.1038/s41598-020-70852-y [doi]
PST - epublish
SO  - Sci Rep. 2020 Aug 17;10(1):13897. doi: 10.1038/s41598-020-70852-y.