PMID- 32808525
OWN - NLM
STAT- MEDLINE
DCOM- 20201211
LR  - 20201214
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 54
IP  - 18
DP  - 2020 Sep 15
TI  - Adipose Tissue Transcriptome Is Related to Pollutant Exposure in Polar Bear 
      Mother-Cub Pairs from Svalbard, Norway.
PG  - 11365-11375
LID - 10.1021/acs.est.0c01920 [doi]
AB  - Being at the food chain apex, polar bears (Ursus maritimus) are highly 
      contaminated with persistent organic pollutants (POPs). Females transfer POPs to 
      their offspring through gestation and lactation; therefore, young cubs present 
      higher POPs concentrations than their mothers. Recent studies suggest that POPs 
      affect the lipid metabolism in female polar bears; however, the mechanisms and 
      impact on their offspring remain unknown. Here, we hypothesized that exposure to 
      POPs differentially alters genome-wide gene transcription in the adipose tissue 
      from mother polar bears and their cubs, highlighting molecular differences in 
      response between adults and young. Adipose tissue biopsies were collected from 13 
      adult female polar bears and their twin cubs in Svalbard, Norway, in April 2011, 
      2012, and 2013. Total RNA extracted from biopsies was subjected to 
      next-generation RNA sequencing. Plasma concentrations of summed polychlorinated 
      biphenyls, organochlorine pesticides, and polybrominated diphenyl ethers in 
      mothers ranged from 897 to 13620 ng/g wet weight and were associated with altered 
      adipose tissue gene expression in both mothers and cubs. In mothers, 2502 and 
      2586 genes in total were positively and negatively, respectively, correlated to 
      POP exposure, whereas in cubs, 2585 positively and 1690 negatively genes. Between 
      mothers and cubs, 743 positively and negatively genes overlapped between mothers 
      and cubs suggesting partially shared molecular responses to SigmaPOPs. 
      SigmaPOP-associated genes were involved in numerous metabolic pathways in mothers and 
      cubs, indicating that POP exposure alters the energy metabolism, which, in turn, 
      may be linked to metabolic dysfunction.
FAU - Herst, Pauline M
AU  - Herst PM
AUID- ORCID: 0000-0003-0869-3676
AD  - Department of Animal Sciences, Centre de Recherche en Reproduction, Developpement 
      et Sante Intergenerationnelle (CRDSI), Laval University, Quebec City G1V 0A6, 
      Canada.
FAU - Aars, Jon
AU  - Aars J
AD  - Norwegian Polar Institute, Fram Centre, NO-9296 Tromso, Norway.
FAU - Joly Beauparlant, Charles
AU  - Joly Beauparlant C
AD  - Computational Biology Laboratory Research Centre, Faculty of Medicine, Laval 
      University, Quebec City G1V 0A6, Canada.
FAU - Bodein, Antoine
AU  - Bodein A
AD  - Computational Biology Laboratory Research Centre, Faculty of Medicine, Laval 
      University, Quebec City G1V 0A6, Canada.
FAU - Dalvai, Mathieu
AU  - Dalvai M
AD  - Department of Animal Sciences, Centre de Recherche en Reproduction, Developpement 
      et Sante Intergenerationnelle (CRDSI), Laval University, Quebec City G1V 0A6, 
      Canada.
FAU - Gagne, Dominic
AU  - Gagne D
AD  - Department of Animal Sciences, Centre de Recherche en Reproduction, Developpement 
      et Sante Intergenerationnelle (CRDSI), Laval University, Quebec City G1V 0A6, 
      Canada.
FAU - Droit, Arnaud
AU  - Droit A
AD  - Computational Biology Laboratory Research Centre, Faculty of Medicine, Laval 
      University, Quebec City G1V 0A6, Canada.
FAU - Bailey, Janice L
AU  - Bailey JL
AD  - Department of Animal Sciences, Centre de Recherche en Reproduction, Developpement 
      et Sante Intergenerationnelle (CRDSI), Laval University, Quebec City G1V 0A6, 
      Canada.
FAU - Routti, Heli
AU  - Routti H
AUID- ORCID: 0000-0001-5560-888X
AD  - Norwegian Polar Institute, Fram Centre, NO-9296 Tromso, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200830
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adipose Tissue/chemistry
MH  - Animals
MH  - *Environmental Pollutants/analysis
MH  - Female
MH  - Humans
MH  - Mothers
MH  - Norway
MH  - *Polychlorinated Biphenyls
MH  - Svalbard
MH  - Transcriptome
MH  - *Ursidae/genetics
EDAT- 2020/08/19 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/08/19 06:00
PHST- 2020/08/19 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/08/19 06:00 [entrez]
AID - 10.1021/acs.est.0c01920 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2020 Sep 15;54(18):11365-11375. doi: 
      10.1021/acs.est.0c01920. Epub 2020 Aug 30.