PMID- 32808566
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20211129
IS  - 1750-7448 (Electronic)
IS  - 1750-743X (Linking)
VI  - 12
IP  - 14
DP  - 2020 Oct
TI  - Neurological adverse events following CAR T-cell therapy: a real-world analysis.
PG  - 1077-1082
LID - 10.2217/imt-2020-0161 [doi]
AB  - Aim: To characterize real-world neurological adverse events (AEs) associated with 
      chimeric antigen receptor T-cell therapies in patients with refractory/relapsed 
      large B-cell lymphomas. Materials & methods: Postmarketing case reports from the 
      US FDA AEs reporting system involving axicabtagene ciloleucel (axi-cel) and 
      tisagenlecleucel (tisa-cel) for large B-cell lymphomas were analyzed. Results: Of 
      804 AE cases identified (637 axi-cel, 167 tisa-cel), 428 (67%) of axi-cel cases 
      and 43 (26%) of tisa-cel cases reported neurological AEs. Compared with cases 
      without neurological AEs, significant associations were observed between 
      neurological AEs and use of axi-cel, age >/=65 years, and the outcome of 
      hospitalization. Conclusion: Neurological AEs were common with chimeric antigen 
      receptor T-cell therapy in the real world and largely reflected those reported in 
      clinical trials.
FAU - Gajra, Ajeet
AU  - Gajra A
AUID- ORCID: 0000-0002-5929-0466
AD  - Cardinal Health Specialty Solutions, Cardinal Health, Dublin, OH 43017, USA.
FAU - Zettler, Marjorie E
AU  - Zettler ME
AD  - Cardinal Health Specialty Solutions, Cardinal Health, Dublin, OH 43017, USA.
FAU - Phillips, Eli G Jr
AU  - Phillips EG Jr
AD  - Cardinal Health Specialty Solutions, Cardinal Health, Dublin, OH 43017, USA.
FAU - Klink, Andrew J
AU  - Klink AJ
AD  - Cardinal Health Specialty Solutions, Cardinal Health, Dublin, OH 43017, USA.
FAU - Jonathan K Kish
AU  - Jonathan K Kish
AD  - Cardinal Health Specialty Solutions, Cardinal Health, Dublin, OH 43017, USA.
FAU - Fortier, Stephanie
AU  - Fortier S
AD  - Cardinal Health Specialty Solutions, Cardinal Health, Dublin, OH 43017, USA.
FAU - Mehta, Sonam
AU  - Mehta S
AD  - Cardinal Health Specialty Solutions, Cardinal Health, Dublin, OH 43017, USA.
FAU - Feinberg, Bruce A
AU  - Feinberg BA
AD  - Cardinal Health Specialty Solutions, Cardinal Health, Dublin, OH 43017, USA.
LA  - eng
PT  - Journal Article
DEP - 20200818
PL  - England
TA  - Immunotherapy
JT  - Immunotherapy
JID - 101485158
RN  - 0 (Antineoplastic Agents, Immunological)
RN  - 0 (Biological Products)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Chimeric Antigen)
RN  - Q6C9WHR03O (tisagenlecleucel)
RN  - U2I8T43Y7R (axicabtagene ciloleucel)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents, Immunological/*adverse effects/therapeutic use
MH  - Biological Products/*adverse effects/therapeutic use
MH  - Female
MH  - Humans
MH  - Lymphoma, Large B-Cell, Diffuse/*drug therapy/immunology
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/*chemically induced
MH  - Receptors, Antigen, T-Cell/*therapeutic use
MH  - Receptors, Chimeric Antigen/*therapeutic use
MH  - T-Lymphocytes/drug effects
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - CAR T-cell therapy
OT  - adverse events
OT  - neurotoxicity
EDAT- 2020/08/19 06:00
MHDA- 2021/11/30 06:00
CRDT- 2020/08/19 06:00
PHST- 2020/08/19 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2020/08/19 06:00 [entrez]
AID - 10.2217/imt-2020-0161 [doi]
PST - ppublish
SO  - Immunotherapy. 2020 Oct;12(14):1077-1082. doi: 10.2217/imt-2020-0161. Epub 2020 
      Aug 18.