PMID- 32810190
OWN - NLM
STAT- MEDLINE
DCOM- 20201014
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 8
DP  - 2020
TI  - HLA-DRB1 allele and autoantibody profiles in Japanese patients with inclusion 
      body myositis.
PG  - e0237890
LID - 10.1371/journal.pone.0237890 [doi]
LID - e0237890
AB  - INTRODUCTION: Inclusion body myositis (IBM) is an idiopathic inflammatory 
      myopathy, characterized by unique clinical features including finger flexor and 
      quadriceps muscle weakness and a lack of any reliable treatment. The human 
      leukocyte antigen (HLA)-DRB1 allele and autoantibody profiles in Japanese IBM 
      patients have not been fully elucidated. METHODS: We studied 83 Japanese IBM 
      patients with a mean age of 69 years (49 males and 34 females) who participated 
      in the 'Integrated Diagnosis Project for Inflammatory Myopathies' from January 
      2011 to September 2016. IBM was diagnosed by histological diagnosis. Various 
      autoantibodies were screened by RNA immunoprecipitation and enzyme-linked 
      immunosorbent assays. HLA-DRB1 genotyping was performed using polymerase chain 
      reaction-sequence based typing. A total of 460 unrelated healthy Japanese 
      controls were also studied. RESULTS: The allele frequencies of DRB1*01:01, 
      DRB1*04:10, and DRB1*15:02 were significantly higher in the IBM group than in the 
      healthy control group (Corrected P = 0.00078, 0.00038 and 0.0046). There was a 
      weak association between the DRB1*01:01 allele and severe leg muscle weakness and 
      muscle atrophy. While hepatitis type C virus infection and autoantibodies to 
      cytosolic 5'-nucleotidase 1A were found in 18 and 28 patients, respectively, no 
      significant association with HLA-DRB1 alleles was observed. CONCLUSION: Japanese 
      IBM patients had the specific HLA-DRB1 allele and autoantibody profiles.
FAU - Oyama, Munenori
AU  - Oyama M
AD  - Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
FAU - Ohnuki, Yuko
AU  - Ohnuki Y
AD  - Department of Medial Ethics, Tokai University School of Medicine, Kanagawa, 
      Japan.
FAU - Inoue, Michio
AU  - Inoue M
AD  - Department of Neuromuscular Research, National Institute of Neuroscience, and 
      Department of Genome Medicine Development, Medical Genome Center, National Center 
      of Neurology and Psychiatry, Tokyo, Japan.
FAU - Uruha, Akinori
AU  - Uruha A
AUID- ORCID: 0000-0002-4758-183X
AD  - Department of Neuropathology, Charite-Universitatsmedizin, Berlin, Germany.
FAU - Yamashita, Satoshi
AU  - Yamashita S
AUID- ORCID: 0000-0001-9315-3492
AD  - Depertment of Neurology, Graduate School of Medical Science, Kumamoto University, 
      Kumamoto, Japan.
FAU - Yutani, Sachiko
AU  - Yutani S
AD  - Department of Neurology, Tokai University School of Medicine, Isehara-shi, 
      Kanagawa, Japan.
FAU - Tanboon, Jantima
AU  - Tanboon J
AD  - Department of Neuromuscular Research, National Institute of Neuroscience, and 
      Department of Genome Medicine Development, Medical Genome Center, National Center 
      of Neurology and Psychiatry, Tokyo, Japan.
FAU - Nakahara, Jin
AU  - Nakahara J
AD  - Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
FAU - Suzuki, Shingo
AU  - Suzuki S
AD  - Department of Molecular Life Science, Basic Medical Science and Molecular 
      Medicine, Tokai University School of Medicine, Kanagawa, Japan.
FAU - Shiina, Takashi
AU  - Shiina T
AD  - Department of Molecular Life Science, Basic Medical Science and Molecular 
      Medicine, Tokai University School of Medicine, Kanagawa, Japan.
FAU - Nishino, Ichizo
AU  - Nishino I
AD  - Department of Neuromuscular Research, National Institute of Neuroscience, and 
      Department of Genome Medicine Development, Medical Genome Center, National Center 
      of Neurology and Psychiatry, Tokyo, Japan.
FAU - Suzuki, Shigeaki
AU  - Suzuki S
AD  - Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200818
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antibodies, Viral)
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Aged
MH  - *Alleles
MH  - Antibodies, Viral/immunology
MH  - Asian People/*genetics
MH  - Autoantibodies/*blood
MH  - Female
MH  - Gene Frequency/genetics
MH  - HLA-DRB1 Chains/*genetics/*immunology
MH  - Hepacivirus/immunology
MH  - Humans
MH  - Male
MH  - Myositis, Inclusion Body/*blood/*genetics/immunology
PMC - PMC7437458
COIS- Munenori Oyama, Yuko Ohnuki, Michio Inoue, Akinori Uruha, Satoshi Yamashita, 
      Sachiko Yutani, Jantima Tanboon, Jin Nakahara, Shingo Suzuki, Takashi Shiina, and 
      Ichizo Nishino declare no competing interests. Shigeaki Suzuki received personal 
      fees from Alexion Pharmaceuticals, the Japan Blood Products Organization, and 
      Asahi Kasei Medical. This does not alter our adherence to PLOS ONE policies on 
      sharing data and materials.
EDAT- 2020/08/19 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/08/18
CRDT- 2020/08/19 06:00
PHST- 2020/06/01 00:00 [received]
PHST- 2020/08/04 00:00 [accepted]
PHST- 2020/08/19 06:00 [entrez]
PHST- 2020/08/19 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/08/18 00:00 [pmc-release]
AID - PONE-D-20-16597 [pii]
AID - 10.1371/journal.pone.0237890 [doi]
PST - epublish
SO  - PLoS One. 2020 Aug 18;15(8):e0237890. doi: 10.1371/journal.pone.0237890. 
      eCollection 2020.