PMID- 32810589
OWN - NLM
STAT- MEDLINE
DCOM- 20210513
LR  - 20210513
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 145
DP  - 2020 Nov
TI  - Enzymatic assays for the assessment of toxic effects of halogenated organic 
      contaminants in water and food. A review.
PG  - 111677
LID - S0278-6915(20)30567-6 [pii]
LID - 10.1016/j.fct.2020.111677 [doi]
AB  - Halogenated organic compounds are a particular group of contaminants consisting 
      of a large number of substances, and of great concern due to their persistence in 
      the environment, potential for bioaccumulation and toxicity. Some of these 
      compounds have been classified as persistent organic pollutants (POPs) under The 
      Stockholm Convention and many toxicity assessments have been conducted on them 
      previously. In this work we provide an overview of enzymatic assays used in these 
      studies to establish toxic effects and dose-response relationships. Studies in 
      vivo and in vitro have been considered with a particular emphasis on the impact 
      of halogenated compounds on the activity of relevant enzymes to the humans and 
      the environment. Most information available in the literature focuses on 
      chlorinated compounds, but brominated and fluorinated molecules are also the 
      target of increasing numbers of studies. The enzymes identified can be classified 
      as enzymes: i) the activities of which are affected by the presence of 
      halogenated organic compounds, and ii) those involved in their 
      metabolisation/detoxification resulting in increased activities. In both cases 
      the halogen substituent seems to have an important role in the effects observed. 
      Finally, the use of these enzymes in biosensing tools for monitoring of 
      halogenated compounds is described.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Artabe, Amaia Ereno
AU  - Artabe AE
AD  - AZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque 
      Tecnologico de Bizkaia, Astondo Bidea, Edificio 609, 48160 Derio, Bizkaia, Spain.
FAU - Cunha-Silva, Hugo
AU  - Cunha-Silva H
AD  - AZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque 
      Tecnologico de Bizkaia, Astondo Bidea, Edificio 609, 48160 Derio, Bizkaia, Spain.
FAU - Barranco, Alejandro
AU  - Barranco A
AD  - AZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque 
      Tecnologico de Bizkaia, Astondo Bidea, Edificio 609, 48160 Derio, Bizkaia, Spain. 
      Electronic address: abarranco@azti.es.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200815
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Enzymes)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Environmental Monitoring/*methods
MH  - Enzyme Assays/*methods
MH  - Enzymes/*chemistry
MH  - Food Contamination/*analysis
MH  - Halogenation
MH  - Water Pollutants, Chemical/*chemistry
OTO - NOTNLM
OT  - Biosensors
OT  - Enzymes
OT  - Halogenated organic contaminants
OT  - In vitro
OT  - In vivo
OT  - Toxicity
EDAT- 2020/08/19 06:00
MHDA- 2021/05/14 06:00
CRDT- 2020/08/19 06:00
PHST- 2020/03/11 00:00 [received]
PHST- 2020/06/05 00:00 [revised]
PHST- 2020/08/04 00:00 [accepted]
PHST- 2020/08/19 06:00 [pubmed]
PHST- 2021/05/14 06:00 [medline]
PHST- 2020/08/19 06:00 [entrez]
AID - S0278-6915(20)30567-6 [pii]
AID - 10.1016/j.fct.2020.111677 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2020 Nov;145:111677. doi: 10.1016/j.fct.2020.111677. Epub 2020 
      Aug 15.