PMID- 3281109
OWN - NLM
STAT- MEDLINE
DCOM- 19880512
LR  - 20190828
IS  - 0301-0449 (Print)
IS  - 0301-0449 (Linking)
VI  - 18
IP  - 2
DP  - 1988
TI  - Pulmonary fungal infections after bone marrow transplantation.
PG  - 118-22
AB  - Of 319 pediatric patients treated with bone marrow transplantation (BMT) during a 
      10-year period, 27 developed pulmonary fungal infections (PFI). Only 2 patients 
      (7%) survived. Twenty-three patients (85%) had been treated with systemic 
      antifungal therapy immediately before or at the time of diagnosis. Nineteen 
      patients (70%) were neutropenic, and 4 of the 8 patients who were not neutropenic 
      were being treated with systemic steroids for graft vs. host disease (GVHD). 
      Seven patients (26%) died within 7 days of diagnosis. The diagnosis was made 
      ante-mortem in 9 patients (33%). Radiographic abnormalities were variable. At the 
      onset of chest X-ray (CXR) change, the pulmonary infiltrates were unilateral in 
      14 patients (52%) and, at diagnosis, bilateral in 18 (66%). At diagnosis the 
      infiltrates were interstitial in 3 patients (11%), alveolar in 20 (74%) and mixed 
      in 4 (15%). Six patients (22%) developed cavitary lesions. The infecting agents 
      were Aspergillus in 21 patients (78%), Candida in 7 (26%), Mucormycosis in 3 
      (11%), and Fusarium in 1 (4%). Five patients (19%) had mixed fungal infections 
      and 7 (26%) had concurrent cytomegalovirus (CMV) pulmonary infections. Although 
      the radiographic changes are often nonspecific in PFI, alveolar or nodular 
      infiltrates in neutropenic patients or in those being treated for GVHD should 
      strongly suggest a fungal etiology.
FAU - Allan, B T
AU  - Allan BT
AD  - Department of Diagnostic Radiology, University of Minnesota Medical School, 
      Minneapolis.
FAU - Patton, D
AU  - Patton D
FAU - Ramsey, N K
AU  - Ramsey NK
FAU - Day, D L
AU  - Day DL
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pediatr Radiol
JT  - Pediatric radiology
JID - 0365332
SB  - IM
MH  - Aspergillosis/etiology
MH  - *Bone Marrow Transplantation
MH  - Candidiasis/etiology
MH  - Humans
MH  - Lung Diseases, Fungal/*etiology
MH  - Mucormycosis/etiology
MH  - Pediatrics
MH  - *Postoperative Complications
MH  - Retrospective Studies
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1007/BF02387554 [doi]
PST - ppublish
SO  - Pediatr Radiol. 1988;18(2):118-22. doi: 10.1007/BF02387554.