PMID- 32812475
OWN - NLM
STAT- MEDLINE
DCOM- 20211122
LR  - 20211122
IS  - 1744-8301 (Electronic)
IS  - 1479-6694 (Linking)
VI  - 16
IP  - 33
DP  - 2020 Nov
TI  - Dysregulated microRNAs in laryngeal cancer: a comprehensive meta-analysis using a 
      robust rank aggregation approach.
PG  - 2723-2734
LID - 10.2217/fon-2020-0394 [doi]
AB  - We need a reasonable method of compiling data from different studies regarding 
      the expression of microRNA (miRNA) in laryngeal squamous cell carcinoma (LSCC). 
      The robust rank aggregation method was used to integrate the rank lists of miRNAs 
      from 11 studies. The enrichment analysis was performed on target genes of 
      meta-signature miRNAs. The Cancer Genome Atlas database was used to confirm the 
      results of meta-analysis. Three meta-signature miRNAs (miR-21-5p, miR-196a-5p and 
      miR-145-5p) were obtained. All three miRNAs could be prognostic for LSCC. The 
      enrichment analysis showed that these miRNAs were associated significantly with 
      multiple cancer-related signaling pathways. The robust rank aggregation approach 
      is an effective way to identify important miRNAs from different studies. All 
      identified miRNAs could be candidates for LSCC diagnostic and prognostic 
      biomarkers.
FAU - Cao, Zaizai
AU  - Cao Z
AD  - Zhejiang University, Zhejiang Province, 310003, PR China.
AD  - Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Zhejiang Province, 310003, PR China.
FAU - Guo, Yu
AU  - Guo Y
AD  - Zhejiang University, Zhejiang Province, 310003, PR China.
AD  - Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Zhejiang Province, 310003, PR China.
FAU - Ao, Yinjie
AU  - Ao Y
AD  - Zhejiang University, Zhejiang Province, 310003, PR China.
AD  - Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Zhejiang Province, 310003, PR China.
FAU - Zhou, Shuihong
AU  - Zhou S
AUID- ORCID: 0000-0002-7163-2289
AD  - Zhejiang University, Zhejiang Province, 310003, PR China.
AD  - Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Zhejiang Province, 310003, PR China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20200819
PL  - England
TA  - Future Oncol
JT  - Future oncology (London, England)
JID - 101256629
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Biomarkers, Tumor
MH  - Computational Biology/methods
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/*genetics/metabolism/mortality
MH  - MicroRNAs/*genetics
MH  - Prognosis
MH  - Signal Transduction
MH  - Squamous Cell Carcinoma of Head and Neck/genetics
OTO - NOTNLM
OT  - gene oncology
OT  - laryngeal squamous cell cancer
OT  - miRNA
OT  - prognosis
OT  - robust rank aggregation
EDAT- 2020/08/20 06:00
MHDA- 2021/11/23 06:00
CRDT- 2020/08/20 06:00
PHST- 2020/08/20 06:00 [pubmed]
PHST- 2021/11/23 06:00 [medline]
PHST- 2020/08/20 06:00 [entrez]
AID - 10.2217/fon-2020-0394 [doi]
PST - ppublish
SO  - Future Oncol. 2020 Nov;16(33):2723-2734. doi: 10.2217/fon-2020-0394. Epub 2020 
      Aug 19.