PMID- 32812932
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 2589-9368 (Electronic)
IS  - 2589-9368 (Linking)
VI  - 6
DP  - 2020 Jun
TI  - Intra-individual reproducibility of galectin-1, haptoglobin, and nesfatin-1 as 
      promising new biomarkers of immunometabolism.
PG  - 100034
LID - 10.1016/j.metop.2020.100034 [doi]
LID - 100034
AB  - BACKGROUND: Galectin-1, haptoglobin, and nesfatin-1 have recently emerged as 
      promising biomarkers implicated in immunometabolism. However, whether single 
      blood measurements of these analytes could be suitable for large-scale human 
      studies has not yet been evaluated. METHODS: The concentrations of galectin-1, 
      haptoglobin, and nesfatin-1 were measured over a 4-month period in 207 healthy 
      adults with median age of 56.7 years. Biomarker intra-individual reproducibility 
      was assessed based on calculation of intraclass correlation coefficients (ICCs) 
      and examining Bland-Altman plots. RESULTS: The overall ICCs were excellent for 
      nesfatin-1 (ICC: 0.89 (95% CI: 0.86, 0.92), and good for galectin-1 and 
      haptoglobin (ICCs: 0.70 (95% CI: 0.61, 0.77) and 0.67 (95% CI: 0.57, 0.74), 
      respectively). Bland-Altman plots supported a high level of agreement between 
      repeated biomarker measurements. CONCLUSIONS: Assay measurements of galectin-1, 
      haptoglobin, and nesfatin-1 showed good to excellent within-subject 
      reproducibility over a 4-month period, indicating that they may serve as feasible 
      and reliable biomarkers for assessing metabolic inflammation in population 
      research.
CI  - (c) 2020 The Authors.
FAU - Schenk, Matthew
AU  - Schenk M
AD  - Senior Scientist Group Nutrition, Immunity and Metabolism, Department of 
      Nutrition and Gerontology, German Institute of Human Nutrition 
      Potsdam-Rehbruecke, Nuthetal, Germany.
FAU - Reichmann, Robin
AU  - Reichmann R
AD  - Senior Scientist Group Nutrition, Immunity and Metabolism, Department of 
      Nutrition and Gerontology, German Institute of Human Nutrition 
      Potsdam-Rehbruecke, Nuthetal, Germany.
AD  - University of Potsdam, Institute of Nutritional Science, Potsdam, Germany.
FAU - Koelman, Liselot
AU  - Koelman L
AD  - Senior Scientist Group Nutrition, Immunity and Metabolism, Department of 
      Nutrition and Gerontology, German Institute of Human Nutrition 
      Potsdam-Rehbruecke, Nuthetal, Germany.
AD  - University of Potsdam, Institute of Nutritional Science, Potsdam, Germany.
FAU - Pfeiffer, Andreas F H
AU  - Pfeiffer AFH
AD  - German Centre for Diabetes Research, Germany.
AD  - Research Group Clinical Nutrition, German Institute of Human Nutrition 
      Potsdam-Rehbruecke, Nuthetal, Germany.
AD  - Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, 
      Charite University Medicine, Berlin, Germany.
FAU - Rudovich, Natalia N
AU  - Rudovich NN
AD  - German Centre for Diabetes Research, Germany.
AD  - Division of Endocrinology and Diabetes, Department of Internal Medicine, Spital 
      Bulach, Bulach, Switzerland.
FAU - Aleksandrova, Krasimira
AU  - Aleksandrova K
AD  - Senior Scientist Group Nutrition, Immunity and Metabolism, Department of 
      Nutrition and Gerontology, German Institute of Human Nutrition 
      Potsdam-Rehbruecke, Nuthetal, Germany.
AD  - University of Potsdam, Institute of Nutritional Science, Potsdam, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200318
PL  - England
TA  - Metabol Open
JT  - Metabolism open
JID - 101767753
PMC - PMC7424788
OTO - NOTNLM
OT  - BMI, body mass index
OT  - ELISA- Enzyme-Linked Immunosorbent Assay. Hb, hemoglobin. hsCRP
OT  - EPIC, European Prospective Investigation into Cancer and Nutrition
OT  - IQR, interquartile range
OT  - Intra-individual reproducibility
OT  - Repeated measurements
OT  - galectin-1
OT  - haptoglobin
OT  - high sensitivity C-reactive protein. ICC, intraclass correlation coefficient
OT  - nesfatin-1
COIS- The authors declare no conflicts of interest.
EDAT- 2020/08/20 06:00
MHDA- 2020/08/20 06:01
PMCR- 2020/03/18
CRDT- 2020/08/20 06:00
PHST- 2020/01/27 00:00 [received]
PHST- 2020/03/11 00:00 [revised]
PHST- 2020/03/15 00:00 [accepted]
PHST- 2020/08/20 06:00 [entrez]
PHST- 2020/08/20 06:00 [pubmed]
PHST- 2020/08/20 06:01 [medline]
PHST- 2020/03/18 00:00 [pmc-release]
AID - S2589-9368(20)30014-1 [pii]
AID - 100034 [pii]
AID - 10.1016/j.metop.2020.100034 [doi]
PST - epublish
SO  - Metabol Open. 2020 Mar 18;6:100034. doi: 10.1016/j.metop.2020.100034. eCollection 
      2020 Jun.