PMID- 32813042
OWN - NLM
STAT- MEDLINE
DCOM- 20211019
LR  - 20240226
IS  - 1432-1912 (Electronic)
IS  - 0028-1298 (Linking)
VI  - 394
IP  - 1
DP  - 2021 Jan
TI  - Short- and long-term effects of rapamycin on ischemic damage and apoptotic 
      changes in torsion of rat testes.
PG  - 85-94
LID - 10.1007/s00210-020-01965-4 [doi]
AB  - Rapamycin has antioxidant defense mechanisms and immune suppressive effects. To 
      detect the short- and long-term effects of rapamycin on ischemic damage and 
      apoptotic changes in torsion of rat testes, mature male albino Wistar rats 
      (n = 48) were included in the study as control, sham, early torsion-detorsion 
      (T/D), early rapamycin treatment, early rapamycin control, late T/D, late 
      rapamycin treatment, and late rapamycin control. The right testis was rotated 
      720 degrees  in a clockwise direction during 4 h in operation groups. Rapamycin was 
      administered orally three times: 30 min before detorsion and 24 and 48 h after 
      detorsion. The animals were killed on the third day in early groups and on the 
      tenth day in late groups after detorsion. Statistically significant differences 
      among all groups were detected for SOD and TBARS, mean seminiferous tubule 
      diameter (MSTD) and Cosentino's histologic score (CHS), caspase 3, bax, average 
      number of apoptotic cells per tubule (ANPCT), and percentage of apoptotic tubule 
      (PAT) values. ANPCT values ​​were 10% lower in the rapamycin treatment groups 
      compared with the untreated T/D groups, and the PAT values ​​were also 
      approximately 1.3 times lower. Although short-term usage of rapamycin may reduce 
      to the tubular injury caused by I/R conversely to apoptosis in the testicular 
      tissue after testicular torsion, rapamycin may have the potential to increase the 
      long-term apoptosis with/without testicular torsion and a subsequent regression 
      in fertility.
FAU - Kabaklioglu, Murat
AU  - Kabaklioglu M
AD  - Department of Pediatric Surgery, Duzce University Medical Faculty, Duzce, Turkey. 
      mkabaklioglu@gmail.com.
FAU - Kaya, Murat
AU  - Kaya M
AD  - Department of Pediatric Surgery, Duzce University Medical Faculty, Duzce, Turkey.
FAU - Sahin, Ibrahim Ethem
AU  - Sahin IE
AD  - Department of Medical Biochemistry, Duzce University Medical Faculty, Duzce, 
      Turkey.
FAU - Gamsizkan, Mehmet
AU  - Gamsizkan M
AD  - Department of Medical Pathology, Duzce University Medical Faculty, Duzce, Turkey.
FAU - Bahcivan, Atike
AU  - Bahcivan A
AD  - Department of Medical Pathology, Duzce University Medical Faculty, Duzce, Turkey.
FAU - Eroz, Recep
AU  - Eroz R
AD  - Department of Medical Genetics, Duzce University Medical Faculty, Duzce, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200819
PL  - Germany
TA  - Naunyn Schmiedebergs Arch Pharmacol
JT  - Naunyn-Schmiedeberg's archives of pharmacology
JID - 0326264
RN  - 0 (Protective Agents)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Ischemia/*drug therapy/metabolism/pathology
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress/drug effects
MH  - Protective Agents/pharmacology/*therapeutic use
MH  - Rats, Wistar
MH  - Sirolimus/pharmacology/*therapeutic use
MH  - Spermatic Cord Torsion/*drug therapy/metabolism/pathology
MH  - Superoxide Dismutase/metabolism
MH  - Testis/drug effects/metabolism/pathology
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Rats
OTO - NOTNLM
OT  - Apoptosis
OT  - Ischemic injury
OT  - Rapamycin
OT  - Testicular torsion and detorsion
EDAT- 2020/08/20 06:00
MHDA- 2021/10/21 06:00
CRDT- 2020/08/20 06:00
PHST- 2020/05/08 00:00 [received]
PHST- 2020/08/10 00:00 [accepted]
PHST- 2020/08/20 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2020/08/20 06:00 [entrez]
AID - 10.1007/s00210-020-01965-4 [pii]
AID - 10.1007/s00210-020-01965-4 [doi]
PST - ppublish
SO  - Naunyn Schmiedebergs Arch Pharmacol. 2021 Jan;394(1):85-94. doi: 
      10.1007/s00210-020-01965-4. Epub 2020 Aug 19.