PMID- 32813736
OWN - NLM
STAT- MEDLINE
DCOM- 20201013
LR  - 20240220
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 8
DP  - 2020
TI  - Relations between plasma microRNAs, echocardiographic markers of atrial 
      remodeling, and atrial fibrillation: Data from the Framingham Offspring study.
PG  - e0236960
LID - 10.1371/journal.pone.0236960 [doi]
LID - e0236960
AB  - BACKGROUND: Circulating microRNAs may reflect or influence pathological cardiac 
      remodeling and contribute to atrial fibrillation (AF). OBJECTIVE: The purpose of 
      this study was to identify candidate plasma microRNAs that are associated with 
      echocardiographic phenotypes of atrial remodeling, and incident and prevalent AF 
      in a community-based cohort. METHODS: We analyzed left atrial function index 
      (LAFI) of 1788 Framingham Offspring 8 participants. We quantified expression of 
      339 plasma microRNAs. We examined associations between microRNA levels with LAFI 
      and prevalent and incident AF. We constructed pathway analysis of microRNAs' 
      predicted gene targets to identify molecular processes involved in adverse atrial 
      remodeling in AF. RESULTS: The mean age of the participants was 66 +/- 9 years, and 
      54% were women. Five percent of participants had prevalent AF at the initial 
      examination and 9% (n = 157) developed AF over a median 8.6 years of follow-up 
      (IQR 8.1-9.2 years). Plasma microRNAs were associated with LAFI (N = 73, 
      p<0.0001). Six of these plasma microRNAs were significantly associated with 
      incident AF, including 4 also associated with prevalent AF (microRNAs 106b, 
      26a-5p, 484, 20a-5p). These microRNAs are predicted to regulate genes involved in 
      cardiac hypertrophy, inflammation, and myocardial fibrosis. CONCLUSIONS: 
      Circulating microRNAs 106b, 26a-5p, 484, 20a-5p are associated with atrial 
      remodeling and AF.
FAU - Vaze, Aditya
AU  - Vaze A
AUID- ORCID: 0000-0001-6139-3985
AD  - Division of Cardiology, Department of Medicine, University of Massachusetts 
      Medical School, Worcester, Massachusetts, United States of America.
FAU - Tran, Khanh-Van
AU  - Tran KV
AD  - Division of Cardiology, Department of Medicine, University of Massachusetts 
      Medical School, Worcester, Massachusetts, United States of America.
FAU - Tanriverdi, Kahraman
AU  - Tanriverdi K
AD  - Division of Cardiology, Department of Medicine, University of Massachusetts 
      Medical School, Worcester, Massachusetts, United States of America.
FAU - Sardana, Mayank
AU  - Sardana M
AD  - Division of Cardiology, Department of Medicine, University of Massachusetts 
      Medical School, Worcester, Massachusetts, United States of America.
FAU - Lessard, Darleen
AU  - Lessard D
AD  - Division of Epidemiology of Chronic Diseases, Department of Quantitative Health 
      Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, 
      United States of America.
FAU - Donahue, J Kevin
AU  - Donahue JK
AD  - Division of Cardiology, Department of Medicine, University of Massachusetts 
      Medical School, Worcester, Massachusetts, United States of America.
FAU - Barton, Bruce
AU  - Barton B
AD  - Biostatistics and Health Services Research, Department of Quantitative Health 
      Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, 
      United States of America.
FAU - Aurigemma, Gerard
AU  - Aurigemma G
AD  - Division of Cardiology, Department of Medicine, University of Massachusetts 
      Medical School, Worcester, Massachusetts, United States of America.
FAU - Lubitz, Steven A
AU  - Lubitz SA
AD  - Cardiovascular Research Center, Massachusetts General Hospital, Boston, 
      Massachusetts, United States of America.
FAU - Lin, Honghuang
AU  - Lin H
AD  - National Heart Lung and Blood Institute's and Boston University's Framingham 
      Heart Study, Framingham, Massachusetts; Computational Biomedicine Section, 
      Department of Medicine, Boston University School of Medicine, Boston, 
      Massachusetts, United States of America.
FAU - Nasr, George H
AU  - Nasr GH
AD  - Department of Medicine, University of California Irvine, Orange, California, 
      United States of America.
FAU - Mandapati, Amiya
AU  - Mandapati A
AD  - Division of Cardiology, Department of Medicine, University of Massachusetts 
      Medical School, Worcester, Massachusetts, United States of America.
FAU - Benjamin, Emelia J
AU  - Benjamin EJ
AUID- ORCID: 0000-0003-4076-2336
AD  - Department of Medicine, and Department of Epidemiology, Boston University's and 
      National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, 
      Massachusetts; Section of Preventive Medicine and Epidemiology and Cardiovascular 
      Medicine, Boston University Schools of Medicine and Public Health, Boston, 
      Massachusetts, United States of America.
FAU - Vasan, Ramachandran S
AU  - Vasan RS
AD  - Department of Medicine, and Department of Epidemiology, Boston University's and 
      National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, 
      Massachusetts; Section of Preventive Medicine and Epidemiology and Cardiovascular 
      Medicine, Boston University Schools of Medicine and Public Health, Boston, 
      Massachusetts, United States of America.
FAU - Freedman, Jane E
AU  - Freedman JE
AD  - Division of Cardiology, Department of Medicine, University of Massachusetts 
      Medical School, Worcester, Massachusetts, United States of America.
FAU - McManus, David D
AU  - McManus DD
AD  - Division of Cardiology, Department of Medicine, University of Massachusetts 
      Medical School, Worcester, Massachusetts, United States of America.
LA  - eng
GR  - KL2 RR031981/RR/NCRR NIH HHS/United States
GR  - K23 HL114724/HL/NHLBI NIH HHS/United States
GR  - R01 HL135219/HL/NHLBI NIH HHS/United States
GR  - R01 HL137734/HL/NHLBI NIH HHS/United States
GR  - N01 HC025195/HC/NHLBI NIH HHS/United States
GR  - U01 HL105268/HL/NHLBI NIH HHS/United States
GR  - R01 HL130376/HL/NHLBI NIH HHS/United States
GR  - R01 HL137794/HL/NHLBI NIH HHS/United States
GR  - R01 NS017950/NS/NINDS NIH HHS/United States
GR  - R01 HL139731/HL/NHLBI NIH HHS/United States
GR  - UH3 TR000921/TR/NCATS NIH HHS/United States
GR  - R01 HL128914/HL/NHLBI NIH HHS/United States
GR  - R01 HL092577/HL/NHLBI NIH HHS/United States
GR  - R01 HL126911/HL/NHLBI NIH HHS/United States
GR  - HHSN268201500001I/HL/NHLBI NIH HHS/United States
GR  - T32 HL120823/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200819
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
RN  - 0 (Genetic Markers)
RN  - 0 (MIRN106 microRNA, human)
RN  - 0 (MIRN20a microRNA, human)
RN  - 0 (MIRN26A microRNA, human)
RN  - 0 (MIRN484 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*blood/diagnostic imaging/*genetics
MH  - Atrial Function, Left/genetics/physiology
MH  - Atrial Remodeling/*genetics/physiology
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Echocardiography
MH  - Female
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - MicroRNAs/*blood/*genetics
MH  - Middle Aged
PMC - PMC7437902
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/08/20 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/08/19
CRDT- 2020/08/20 06:00
PHST- 2020/03/21 00:00 [received]
PHST- 2020/07/16 00:00 [accepted]
PHST- 2020/08/20 06:00 [entrez]
PHST- 2020/08/20 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/08/19 00:00 [pmc-release]
AID - PONE-D-20-08178 [pii]
AID - 10.1371/journal.pone.0236960 [doi]
PST - epublish
SO  - PLoS One. 2020 Aug 19;15(8):e0236960. doi: 10.1371/journal.pone.0236960. 
      eCollection 2020.