PMID- 32814264
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 129
DP  - 2020 Oct
TI  - Staging of depressive disorders: Relevance of resistance to treatment and 
      residual symptoms.
PG  - 234-240
LID - S0022-3956(20)30887-6 [pii]
LID - 10.1016/j.jpsychires.2020.07.022 [doi]
AB  - BACKGROUND: Clinical staging model for depression helps to better define the 
      clinical situation of patients. The objectives of this study are: to correlate 
      the Hetrick's staging model of depression with the severity of depression, 
      associated disability, and resistance to treatment in the established disease 
      stages and to test the modification introduced by our group consisting in the 
      introduction of a substage for recurrence from a previous episode that was 
      stabilized with a complete remission. METHODS: A Cross-sectional study with 133 
      adult subjects having a current and primary diagnosis of Depressive disorder was 
      developed. Patients were classified according to the model and assessed with: 
      17-item Hamilton Depression Scale (HAM-D), Clinical Global Impression (CGI); 
      Global Assessment of Function (GAF); Maudsley Staging Method for treatment 
      resistance (MSM) and Sheeham Disability Schedule (SDS). RESULTS: The variable 
      that best contributes to the differentiation between clinical stages, in 
      established Depression, is resistance to treatment evaluated by the MSM. 
      Correlations between MSM and the clinical stages were statistically significant 
      between most pairs of stages. Finally, we showed preliminary data in order to 
      prove that a differential sub-stage for recurrent depression with and without 
      inter-episodic remission in the current heuristic models could be a possible 
      stage for better define depression staging model. CONCLUSIONS: Resistance to 
      treatment should be included in the definition of clinical stages in established 
      depression. Despite the difficulty of establishing a valid model for the staging 
      of depression, it can certainly add great value to diagnosis, therapeutic 
      interventions and clinical research.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Reneses, Blanca
AU  - Reneses B
AD  - Instituto de Psiquiatria y Salud Mental, Instituto de Investigacion (IdISSC), 
      Hospital Clinico San Carlos, Madrid, Spain; Facultad de Medicina, Universidad 
      Complutense de Madrid, Spain. Electronic address: blanca@reneses.es.
FAU - Aguera-Ortiz, Luis
AU  - Aguera-Ortiz L
AD  - Servicio de Psiquiatria, Instituto de Investigacion i+12, Hospital Universitario 
      12 de Octubre, Madrid, Spain; Centro de Investigacion Biomedica en Red de Salud 
      Mental (CIBERSAM), Madrid, Spain. Electronic address: Luis@aguera.es.
FAU - Sevilla-Llewellyn-Jones, Julia
AU  - Sevilla-Llewellyn-Jones J
AD  - Instituto de Psiquiatria y Salud Mental, Instituto de Investigacion (IdISSC), 
      Hospital Clinico San Carlos, Madrid, Spain. Electronic address: 
      julia.sevilla@salud.madrid.org.
FAU - Carrillo, Antonio
AU  - Carrillo A
AD  - Instituto de Psiquiatria y Salud Mental, Instituto de Investigacion (IdISSC), 
      Hospital Clinico San Carlos, Madrid, Spain. Electronic address: 
      acargo@telefonica.net.
FAU - Argudo, Isabel
AU  - Argudo I
AD  - Instituto de Psiquiatria y Salud Mental, Instituto de Investigacion (IdISSC), 
      Hospital Clinico San Carlos, Madrid, Spain. Electronic address: 
      isabelmaria.argudo@salud.madrid.org.
FAU - Regatero, Maria Jose
AU  - Regatero MJ
AD  - Instituto de Psiquiatria y Salud Mental, Instituto de Investigacion (IdISSC), 
      Hospital Clinico San Carlos, Madrid, Spain. Electronic address: 
      mjose.regatero@salud.madrid.org.
FAU - Lopez-Mico, Cristina
AU  - Lopez-Mico C
AD  - Instituto de Investigacion (IdISSC), Hospital Clinico San Carlos, Madrid, Spain. 
      Electronic address: cristina.lopez.mico@gmail.com.
FAU - Fuentes, Manuel
AU  - Fuentes M
AD  - Instituto de Investigacion (IdISSC), Hospital Clinico San Carlos, Madrid, Spain. 
      Electronic address: mfuentesferrer@gmail.com.
FAU - Palomo, Tomas
AU  - Palomo T
AD  - Facultad de Medicina, Universidad Complutense de Madrid, Spain; Centro de 
      Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Madrid, Spain; 
      Instituto de Investigacion (IdISSC), Hospital Clinico San Carlos, Madrid, Spain. 
      Electronic address: tomaspalomo@med.ucm.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200722
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - *Depressive Disorder, Major
MH  - Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Remission Induction
MH  - *Sexual and Gender Minorities
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Clinical staging
OT  - Depressive disorders
OT  - Major depression
OT  - Treatment resistance
EDAT- 2020/08/20 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/08/20 06:00
PHST- 2020/03/25 00:00 [received]
PHST- 2020/07/17 00:00 [revised]
PHST- 2020/07/17 00:00 [accepted]
PHST- 2020/08/20 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/08/20 06:00 [entrez]
AID - S0022-3956(20)30887-6 [pii]
AID - 10.1016/j.jpsychires.2020.07.022 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2020 Oct;129:234-240. doi: 10.1016/j.jpsychires.2020.07.022. 
      Epub 2020 Jul 22.