PMID- 32814604
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221222
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 125
IP  - 7
DP  - 2021 Apr 14
TI  - Impact of improving eating habits and rosmarinic acid supplementation on rat 
      vascular and neuronal system in the metabolic syndrome model.
PG  - 757-767
LID - 10.1017/S000711452000327X [doi]
AB  - Decreasing high fat and high carbohydrate intake, together with the 
      administration of natural bioactive drugs, is assumed to have a protective effect 
      in the prevention and amelioration of the metabolic syndrome (MetS). The aim of 
      the study was to evaluate effects of diet improvement and/or a phenolic compound 
      (rosmarinic acid; RA) administration (100 mg/kg per d) on metabolic as well as 
      functional changes of vessels and hippocampus caused by the MetS-like conditions. 
      The MetS-like conditions were induced by a high-fat-fructose diet (HFFD) in 
      Prague hereditary hypertriacylglycerolaemic (HTG) rats. The effect of diet 
      improvement and RA administration was studied using biochemical and functional 
      measurements. Consumption of HFFD by HTG rats resulted in the development of 
      conditions like the MetS. The fat and fructose restriction from the diet led to 
      amelioration of basic indicators of metabolic state in rats fed HFFD and to 
      amendment parameters of glucose tolerance test and reduction of the IL-1beta serum 
      levels. Moreover, aortic endothelial function was improved with an impact on 
      blood pressure. The functional measurement of electrophysiology of the 
      hippocampus showed that long-term potentiation of neuronal transmission course 
      deteriorated after HFFD was improved by energy restriction. Oral administration 
      of RA had a supporting effect not only on lipid and glucose metabolism but also 
      on the vascular endothelium. Combination of both types of therapy induced 
      beneficial effect on glucose tolerance and lipid peroxidation. Thus, combined 
      improvement of diet habits and treatment with natural bioactive drugs is assumed 
      to have protective effect in prevention and amelioration of the MetS.
FAU - Michalikova, D
AU  - Michalikova D
AUID- ORCID: 0000-0002-8233-8499
AD  - Slovak Academy of Sciences, Centre of Experimental Medicine, Institute of 
      Experimental Pharmacology and Toxicology, 841 04Bratislava, Slovak Republic.
AD  - Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 
      01Martin, Slovak Republic.
FAU - Tyukos Kaprinay, B
AU  - Tyukos Kaprinay B
AD  - Slovak Academy of Sciences, Centre of Experimental Medicine, Institute of 
      Experimental Pharmacology and Toxicology, 841 04Bratislava, Slovak Republic.
FAU - Brnoliakova, Z
AU  - Brnoliakova Z
AD  - Slovak Academy of Sciences, Centre of Experimental Medicine, Institute of 
      Experimental Pharmacology and Toxicology, 841 04Bratislava, Slovak Republic.
FAU - Sasvariova, M
AU  - Sasvariova M
AD  - Faculty of Pharmacy, Comenius University in Bratislava, 831 04Bratislava, Slovak 
      Republic.
FAU - Krenek, P
AU  - Krenek P
AD  - Faculty of Pharmacy, Comenius University in Bratislava, 831 04Bratislava, Slovak 
      Republic.
FAU - Babiak, E
AU  - Babiak E
AD  - Faculty of Pharmacy, Comenius University in Bratislava, 831 04Bratislava, Slovak 
      Republic.
FAU - Frimmel, K
AU  - Frimmel K
AD  - Slovak Academy of Sciences, Centre of Experimental Medicine, Institute for Heart 
      Research, 841 04Bratislava, Slovak Republic.
FAU - Bittner Fialova, S
AU  - Bittner Fialova S
AD  - Faculty of Pharmacy, Comenius University in Bratislava, 831 04Bratislava, Slovak 
      Republic.
FAU - Stankovicova, T
AU  - Stankovicova T
AD  - Faculty of Pharmacy, Comenius University in Bratislava, 831 04Bratislava, Slovak 
      Republic.
FAU - Sotnikova, R
AU  - Sotnikova R
AD  - Slovak Academy of Sciences, Centre of Experimental Medicine, Institute of 
      Experimental Pharmacology and Toxicology, 841 04Bratislava, Slovak Republic.
FAU - Gasparova, Z
AU  - Gasparova Z
AD  - Slovak Academy of Sciences, Centre of Experimental Medicine, Institute of 
      Experimental Pharmacology and Toxicology, 841 04Bratislava, Slovak Republic.
LA  - eng
PT  - Journal Article
DEP - 20200820
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
SB  - IM
OTO - NOTNLM
OT  - CVD
OT  - Energy restriction
OT  - Hippocampus
OT  - Hypertriacylglycerolaemic rats
OT  - Metabolic syndrome
OT  - Rosmarinic acid
EDAT- 2020/08/21 06:00
MHDA- 2020/08/21 06:01
CRDT- 2020/08/21 06:00
PHST- 2020/08/21 06:00 [pubmed]
PHST- 2020/08/21 06:01 [medline]
PHST- 2020/08/21 06:00 [entrez]
AID - S000711452000327X [pii]
AID - 10.1017/S000711452000327X [doi]
PST - ppublish
SO  - Br J Nutr. 2021 Apr 14;125(7):757-767. doi: 10.1017/S000711452000327X. Epub 2020 
      Aug 20.