PMID- 32814949
OWN - NLM
STAT- MEDLINE
DCOM- 20201228
LR  - 20201228
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 154
IP  - 6
DP  - 2020 Nov 4
TI  - Giant Cell Carcinosarcoma of the Parotid Gland With a PLAG 1 Translocation in 
      Association With a Pleomorphic Adenoma With HMGA2 Translocation.
PG  - 811-815
LID - 10.1093/ajcp/aqaa104 [doi]
AB  - OBJECTIVES: Carcinosarcomas of the salivary gland are rare neoplasms and have 
      been described arising de novo or in association with pleomorphic adenoma (PA). 
      PLAG1 and HMGA2 translocations are known to occur in PAs and carcinomas ex PA but 
      are mutually exclusive. METHODS: We report a case of a carcinosarcoma in the 
      parotid gland of a 77-year-old man with unusual anaplastic sarcomatoid giant cell 
      morphology. RESULTS: Microscopically, a small separate PA was found adjacent to 
      the carcinosarcoma. By conventional notion, the PA and carcinosarcoma would be 
      considered related, as carcinosarcomas are well known to arise from PAs 
      (carcinosarcoma ex PA). However, fluorescence in situ hybridization (FISH) assay 
      demonstrated PLAG1 translocation in the carcinosarcoma and HMGA2 translocation in 
      the separate PA. CONCLUSIONS: These findings support that the carcinosarcoma 
      likely originated from another PA with a PLAG1 translocation or de novo but not 
      from the coexisting PA harboring a different translocation. To our knowledge, the 
      case is the first to demonstrate PLAG1 translocation by FISH in a sarcomatous 
      component of any parotid gland tumor, which may help better classify these 
      tumors. In addition, multiple PAs are commonly found in the salivary gland, and 
      to our knowledge, our case is the first to demonstrate that the same parotid 
      gland can host PAs and PA-related tumors with different translocations.
CI  - (c) American Society for Clinical Pathology, 2020.
FAU - Katsakhyan, Levon
AU  - Katsakhyan L
AD  - Department of Pathology and Laboratory Medicine, Hospital of the University of 
      Pennsylvania, Philadelphia.
FAU - LiVolsi, Virginia A
AU  - LiVolsi VA
AD  - Department of Pathology and Laboratory Medicine, Hospital of the University of 
      Pennsylvania, Philadelphia.
FAU - Chalian, Ara A
AU  - Chalian AA
AD  - Department of Otorhinolaryngology, Hospital of the University of Pennsylvania, 
      Philadelphia.
FAU - Zhang, Paul J
AU  - Zhang PJ
AD  - Department of Pathology and Laboratory Medicine, Hospital of the University of 
      Pennsylvania, Philadelphia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HMGA2 Protein)
RN  - 0 (HMGA2 protein, human)
RN  - 0 (PLAG1 protein, human)
SB  - IM
MH  - Adenoma, Pleomorphic/genetics/pathology
MH  - Aged
MH  - Carcinosarcoma/genetics/*pathology/therapy
MH  - DNA-Binding Proteins/*genetics
MH  - Giant Cells/*pathology
MH  - HMGA2 Protein/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Parotid Gland/*pathology
MH  - Salivary Gland Neoplasms/genetics/*pathology/therapy
MH  - Tomography, X-Ray Computed
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - HMGA2
OT  - PLAG1
OT  - Carcinosarcoma ex pleomorphic adenoma
OT  - Carcinosarcomas
OT  - Pleomorphic adenoma
OT  - Salivary gland tumors
OT  - Sarcomatoid salivary duct carcinoma ex PA
OT  - True malignant mixed tumor
EDAT- 2020/08/21 06:00
MHDA- 2020/12/29 06:00
CRDT- 2020/08/21 06:00
PHST- 2020/08/21 06:00 [pubmed]
PHST- 2020/12/29 06:00 [medline]
PHST- 2020/08/21 06:00 [entrez]
AID - 5894639 [pii]
AID - 10.1093/ajcp/aqaa104 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2020 Nov 4;154(6):811-815. doi: 10.1093/ajcp/aqaa104.