PMID- 32815053
OWN - NLM
STAT- MEDLINE
DCOM- 20210811
LR  - 20210811
IS  - 1863-2661 (Electronic)
IS  - 1863-2653 (Linking)
VI  - 225
IP  - 8
DP  - 2020 Nov
TI  - Dissociable fronto-striatal functional networks predict choice impulsivity.
PG  - 2377-2386
LID - 10.1007/s00429-020-02128-0 [doi]
AB  - Fronto-striatal structural connectivity is associated with choice impulsivity. 
      Yet, to date, whether distinct fronto-striatal functional coupling associates 
      with impulsive choices are largely unknown. Using seed-based resting-state 
      functional MRI (rsfMRI) combined with multivariate pattern analysis (MVPA), the 
      present study aimed to explore the predictions of dissociable frontal-striatal 
      functional connectivity on choice impulsivity in a relatively large sample 
      (N = 429). Adaptive delay-discounting task was utilized to assess choice 
      impulsivity and the striatum was further divided into three subregions including 
      the nucleus accumbens (NAcc), caudate, and putamen. Results revealed that both 
      the functional coupling between the NAcc and the limbic/dorsolateral prefrontal 
      cortex, and between the caudate and the dorsal prefrontal cortex, including the 
      dorsomedial prefrontal cortex (DMPFC), successfully predicted the 
      delay-discounting rate. However, such pattern was not observed in the 
      putamen-prefrontal functional connectivity. These findings suggest 
      fronto-striatal-dependent neural mechanisms of choice impulsivity and further 
      provide a better understanding of the contributions of striatum subregions and 
      their functional connectivities with different areas of prefrontal cortex upon 
      inter-temporal choice.
FAU - Wang, Qiang
AU  - Wang Q
AUID- ORCID: 0000-0002-1081-6690
AD  - Key Research Base of Humanities and Social Sciences of the Ministry of Education, 
      Academy of Psychology and Behavior, Tianjin Normal University, Tianjin, 300387, 
      China. wangqiang113@gmail.com.
AD  - Faculty of Psychology, Tianjin Normal University, Tianjin, 300387, China. 
      wangqiang113@gmail.com.
AD  - Tianjin Social Science Laboratory of Students' Mental Development and Learning, 
      Tianjin, 300387, China. wangqiang113@gmail.com.
FAU - Lv, Chenyu
AU  - Lv C
AD  - Faculty of Psychology, Southwest University, Chongqing, 400715, China.
FAU - He, Qinghua
AU  - He Q
AD  - Faculty of Psychology, Southwest University, Chongqing, 400715, China. 
      heqinghua@swu.edu.cn.
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, 100101, 
      China. heqinghua@swu.edu.cn.
FAU - Xue, Gui
AU  - Xue G
AD  - National Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern 
      Institute for Brain Research, Beijing Normal University, Beijing, 100875, China. 
      gxue@bnu.edu.cn.
LA  - eng
GR  - 31972906/National Natural Science Foundation of China/
GR  - 20YJC190018/Humanities and Social Sciences Fund Project of the Ministry of 
      Education/
PT  - Journal Article
DEP - 20200819
PL  - Germany
TA  - Brain Struct Funct
JT  - Brain structure & function
JID - 101282001
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Choice Behavior/*physiology
MH  - Corpus Striatum/diagnostic imaging/*physiology
MH  - Delay Discounting/*physiology
MH  - Female
MH  - Frontal Lobe/diagnostic imaging/*physiology
MH  - Functional Neuroimaging
MH  - Humans
MH  - Impulsive Behavior/*physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/diagnostic imaging/physiology
MH  - Neuropsychological Tests
MH  - Young Adult
OTO - NOTNLM
OT  - Choice impulsivity
OT  - Functional connectivity
OT  - Inter-temporal choice
OT  - Multivariate pattern analysis
OT  - Prefrontal cortex
OT  - Striatum
EDAT- 2020/08/21 06:00
MHDA- 2021/08/12 06:00
CRDT- 2020/08/21 06:00
PHST- 2019/11/18 00:00 [received]
PHST- 2020/08/07 00:00 [accepted]
PHST- 2020/08/21 06:00 [pubmed]
PHST- 2021/08/12 06:00 [medline]
PHST- 2020/08/21 06:00 [entrez]
AID - 10.1007/s00429-020-02128-0 [pii]
AID - 10.1007/s00429-020-02128-0 [doi]
PST - ppublish
SO  - Brain Struct Funct. 2020 Nov;225(8):2377-2386. doi: 10.1007/s00429-020-02128-0. 
      Epub 2020 Aug 19.