PMID- 32815194 OWN - NLM STAT- MEDLINE DCOM- 20210602 LR - 20210602 IS - 1365-2885 (Electronic) IS - 0140-7783 (Linking) VI - 43 IP - 5 DP - 2020 Sep TI - Effect of ketoprofen co-administration on pharmacokinetics of cefquinome following repeated administration in goats. PG - 440-447 LID - 10.1111/jvp.12904 [doi] AB - The pharmacokinetics of cefquinome (2 mg/kg every 24 hr for 5 days) was determined following intramuscular administration alone and co-administration with ketoprofen (3 mg/kg every 24 hr for 5 days) in goats. Six goats were used for the study. In the study, the crossover pharmacokinetics design with 20-day washout period was performed in two periods. Plasma concentrations of cefquinome were assayed using high-performance liquid chromatography by ultraviolet detection. The mean terminal elimination half-life (t(1/2ʎz) ), area under the concentration-time curve (AUC(0-24) ), peak concentration (C(max) ), apparent volume of distribution (V(darea) /F), and total body clearance (CL/F) of cefquinome after the administration alone were 4.85 hr, 11.06 hr*microg/ml, 2.37 microg/mL, 1.23 L/kg, and 0.17 L/h/kg after the first dose, and 5.88 hr, 17.01 hr*microg/mL, 3.04 microg/mL, 0.95 L/kg, and 0.11 L/h/kg after the last dose. Ketoprofen significantly prolonged t(1/2ʎz) of cefquinome, increased AUC(0-24) and C(max) , and decreased V(darea) /F and CL/F. Cefquinome exhibited low accumulation after the administration alone and in combination with ketoprofen. These results indicated that ketoprofen prolonged the elimination of cefquinome in goats. The 24-hr dosing intervals at 2 mg/kg dose of cefquinome, which co-administered with ketoprofen, may maintain T> minimum inhibitory concentration (MIC) values above 40% in the treatment of infections caused by susceptible pathogens with the MIC value of