PMID- 32815395 OWN - NLM STAT- MEDLINE DCOM- 20220408 LR - 20220408 IS - 1525-6014 (Electronic) IS - 0148-0545 (Linking) VI - 45 IP - 3 DP - 2022 May TI - Evaluation of 28-day repeated oral dose toxicity of aluminum chloride in rats. PG - 1088-1097 LID - 10.1080/01480545.2020.1808670 [doi] AB - The present study investigated the potential adverse effects of aluminum chloride (AlCl(3)) following a 4-week repeated oral administration in Sprague-Dawley rats. The test article was administered once daily by gavage to male and female rats at dose levels of 0, 100, 300, and 900 mg/kg/day for 4 weeks. After administration of AlCl(3) at 900 mg/kg/day, treatment-related systemic toxicity manifested as significant increases in salivation incidence, neutrophil percentage, reticulocytes, serum triglyceride, adrenal gland and liver weights, and single-hepatocyte necrosis, as well as significant decreases in body weight gain, food intake, hemoglobin, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration (MCHC), lymphocyte percentage, serum total protein and albumin, and thymus weight in male rats; and significant increases in salivation incidence, serum triglyceride, and liver weight, as well as a significant decrease in lymphocyte percentage in female rats. At 300 mg/kg/day, a significant decrease in MCHC was found in male rats, but not in female rats. However, this finding was not toxicologically significant because the reduction was minimal and was not accompanied by changes in any other parameters. No treatment-related effects were observed in the 100 mg/kg/day group of both genders. Under the experimental conditions of this study, the target organs of AlCl(3) were determined to be the blood, liver, and thymus in rats. The no-observed-adverse-effect level was found to be 300 mg/kg/day in rats of both genders. FAU - Lim, Je-Oh AU - Lim JO AD - College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea. FAU - Jung, Tae-Yang AU - Jung TY AD - College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea. FAU - Lee, Se-Jin AU - Lee SJ AD - College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea. FAU - Park, So-Won AU - Park SW AD - College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea. FAU - Kim, Woong-Il AU - Kim WI AD - College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea. FAU - Park, Sung-Hyeuk AU - Park SH AD - College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea. FAU - Kim, Je-Hein AU - Kim JH AD - Bioenvironmental Science & Technology Division, Korea Institute of Toxicology, Jinju, Republic of Korea. FAU - Heo, Jeong-Doo AU - Heo JD AD - Bioenvironmental Science & Technology Division, Korea Institute of Toxicology, Jinju, Republic of Korea. FAU - Kim, Yong-Bum AU - Kim YB AD - Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon, Republic of Korea. FAU - Shin, In-Sik AU - Shin IS AD - College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea. FAU - Kim, Jong-Choon AU - Kim JC AUID- ORCID: 0000-0002-8265-9911 AD - College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea. LA - eng PT - Journal Article DEP - 20200820 PL - United States TA - Drug Chem Toxicol JT - Drug and chemical toxicology JID - 7801723 RN - 0 (Triglycerides) RN - 3CYT62D3GA (Aluminum Chloride) SB - IM MH - Administration, Oral MH - Aluminum Chloride/toxicity MH - Animals MH - Female MH - *Liver MH - Male MH - No-Observed-Adverse-Effect Level MH - Rats MH - Rats, Sprague-Dawley MH - Triglycerides OTO - NOTNLM OT - Aluminum OT - no-observed-adverse-effect level OT - rat OT - systemic toxicity OT - target organ EDAT- 2020/08/21 06:00 MHDA- 2022/04/09 06:00 CRDT- 2020/08/21 06:00 PHST- 2020/08/21 06:00 [pubmed] PHST- 2022/04/09 06:00 [medline] PHST- 2020/08/21 06:00 [entrez] AID - 10.1080/01480545.2020.1808670 [doi] PST - ppublish SO - Drug Chem Toxicol. 2022 May;45(3):1088-1097. doi: 10.1080/01480545.2020.1808670. Epub 2020 Aug 20.