PMID- 32817761
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 12
DP  - 2020
TI  - Relationship between interstitial glucose variability in ambulatory glucose 
      profile and standardized continuous glucose monitoring metrics; a pilot study.
PG  - 70
LID - 10.1186/s13098-020-00577-5 [doi]
LID - 70
AB  - BACKGROUND: Treatment indexes using continuous glucose monitoring (CGM) have 
      become standardized internationally, and the use of ambulatory glucose profile 
      (AGP) is currently recommended. However, the relationship between AGP indexes and 
      standardized CGM metrics has not been investigated. Using flash glucose 
      monitoring (FGM), this retrospective study served to evaluate the association of 
      the inter-quartile range (IQR) of AGP with standardized CGM metrics. METHODS: The 
      study subjects were 30 patients with type 2 diabetes mellitus (T2DM) and 23 
      non-diabetic patients (control group). We evaluated average IQR (AIQR) and 
      standardized CGM metrics. The primary endpoint was the relationship between AIQR 
      and Time in range (TIR) in a 24-h period. RESULTS: In the T2DM group, the AIQR 
      was notably high and correlated negatively with TIR, and positively with Time 
      above range, average interstitial glucose level, standard deviation of 
      interstitial glucose, coefficient of variation of interstitial glucose, and mean 
      of daily difference in blood glucose (MODD). For the T2DM group, the AIQR was 
      notably lower in patients who achieved TIR > 70%, compared to those who did not. 
      The AIQR cutoff value, as determined by ROC analysis, was 28.3 mg/dl for those 
      who achieved TIR > 70%. No association was detected between the presence of 
      hypoglycemia and AIQR. CONCLUSIONS: Our study is the first to provide the AIQR 
      cutoff value for achieving the TIR target value. The range of interstitial 
      glucose variability in AGP was associated with indexes of intra- and interday 
      variations and hyperglycemia. Our results provide new perspectives in the 
      yet-to-be established methods for evaluation of AGP in practical clinical 
      settings.
CI  - (c) The Author(s) 2020.
FAU - Tokutsu, Akemi
AU  - Tokutsu A
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 
      Kitakyushu-Shi, 807-8555 Japan. GRID: grid.271052.3. ISNI: 0000 0004 0374 5913
FAU - Okada, Yosuke
AU  - Okada Y
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 
      Kitakyushu-Shi, 807-8555 Japan. GRID: grid.271052.3. ISNI: 0000 0004 0374 5913
FAU - Torimoto, Keiichi
AU  - Torimoto K
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 
      Kitakyushu-Shi, 807-8555 Japan. GRID: grid.271052.3. ISNI: 0000 0004 0374 5913
FAU - Tanaka, Yoshiya
AU  - Tanaka Y
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 
      Kitakyushu-Shi, 807-8555 Japan. GRID: grid.271052.3. ISNI: 0000 0004 0374 5913
LA  - eng
PT  - Journal Article
DEP - 20200812
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC7424649
OTO - NOTNLM
OT  - Ambulatory Glucose Profile (AGP)
OT  - Flash Glucose Monitoring (FGM)
OT  - Inter-quartile Range (IQR)
OT  - Retrospective study
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2020/08/21 06:00
MHDA- 2020/08/21 06:01
PMCR- 2020/08/12
CRDT- 2020/08/21 06:00
PHST- 2020/06/10 00:00 [received]
PHST- 2020/08/05 00:00 [accepted]
PHST- 2020/08/21 06:00 [entrez]
PHST- 2020/08/21 06:00 [pubmed]
PHST- 2020/08/21 06:01 [medline]
PHST- 2020/08/12 00:00 [pmc-release]
AID - 577 [pii]
AID - 10.1186/s13098-020-00577-5 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2020 Aug 12;12:70. doi: 10.1186/s13098-020-00577-5. 
      eCollection 2020.