PMID- 32818114
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20221012
IS  - 2164-2591 (Print)
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 9
IP  - 4
DP  - 2020 Mar
TI  - Longitudinal Assessment of Remnant Foveal Cone Structure in a Case Series of 
      Early Macular Telangiectasia Type 2.
PG  - 27
LID - 10.1167/tvst.9.4.27 [doi]
LID - 27
AB  - PURPOSE: To determine the extent of remnant cone structure within early foveal 
      ellipsoid zone (EZ) lesions in macular telangiectasia type 2 longitudinally using 
      both confocal and split detector adaptive optics scanning light ophthalmoscopy 
      (AOSLO). METHODS: Spectral domain optical coherence tomography (SDOCT), confocal 
      and split detector AOSLO were acquired from seven patients (10 eyes) with small 
      (early) EZ lesions on SDOCT secondary to macular telangiectasia type 2 at 
      baseline, 6 months, and 12 months. The presence of cone structure on AOSLO in 
      areas of EZ loss as well as cones at 1 degrees  eccentricity, and their change over time 
      were quantified. RESULTS: By split detector AOSLO, remnant cone structure was 
      identified within and on the borders of all foveal EZ lesions. Within the extent 
      of these lesions, cone spacing ranged from 4.97 to 9.95 microm at baseline, 5.30 to 
      6.10 microm at 6 months, and 4.99 to 7.12 microm at 12 months. Four eyes with 
      significantly smaller EZ lesions showed evidence of recovery of EZ reflectivity 
      on SDOCT B-scans. Remnant cone structure was identified in some areas where EZ 
      reflectivity recovered at the following time point. Eyes that showed recovery of 
      EZ reflectivity had a continuous external limiting membrane. CONCLUSIONS: Remnant 
      cone structure can persist within small SDOCT-defined EZ lesions, which can wax 
      and wane in appearance over time. AOSLO can help to inform the interpretation of 
      SDOCT imaging. TRANSLATIONAL RELEVANCE: The absence of EZ in early macular 
      telangiectasia type 2 and other retinal conditions needs careful interpretation 
      because it does not always indicate an absence of underlying cone structure. The 
      integrity of the external limiting membrane may better predict the presence of 
      remnant cone structure and recovery of EZ reflectivity.
CI  - Copyright 2020 The Authors.
FAU - Litts, Katie M
AU  - Litts KM
AD  - Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, 
      USA.
FAU - Okada, Mali
AU  - Okada M
AD  - Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
FAU - Heeren, Tjebo F C
AU  - Heeren TFC
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
AD  - University College London Institute of Ophthalmology, London, UK.
FAU - Kalitzeos, Angelos
AU  - Kalitzeos A
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
AD  - University College London Institute of Ophthalmology, London, UK.
FAU - Rocco, Vincent
AU  - Rocco V
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
FAU - Mastey, Rebecca R
AU  - Mastey RR
AD  - Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, 
      USA.
FAU - Singh, Navjit
AU  - Singh N
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
AD  - University College London Institute of Ophthalmology, London, UK.
FAU - Kane, Thomas
AU  - Kane T
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
AD  - University College London Institute of Ophthalmology, London, UK.
FAU - Kasilian, Melissa
AU  - Kasilian M
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
AD  - University College London Institute of Ophthalmology, London, UK.
FAU - Fruttiger, Marcus
AU  - Fruttiger M
AD  - University College London Institute of Ophthalmology, London, UK.
FAU - Michaelides, Michel
AU  - Michaelides M
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
AD  - University College London Institute of Ophthalmology, London, UK.
FAU - Carroll, Joseph
AU  - Carroll J
AD  - Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, 
      USA.
AD  - Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, 
      WI, USA.
FAU - Egan, Catherine
AU  - Egan C
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
AD  - University College London Institute of Ophthalmology, London, UK.
LA  - eng
GR  - C06 RR016511/RR/NCRR NIH HHS/United States
GR  - R01 EY017607/EY/NEI NIH HHS/United States
GR  - UL1 TR001436/TR/NCATS NIH HHS/United States
GR  - P30 EY001931/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200330
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
MH  - *Fovea Centralis
MH  - Humans
MH  - Ophthalmoscopy
MH  - Retinal Cone Photoreceptor Cells
MH  - Visual Acuity
PMC - PMC7396184
OTO - NOTNLM
OT  - adaptive optics scanning light ophthalmoscopy
OT  - cones
OT  - ellipsoid zone
OT  - macular telangiectasia
COIS- Disclosure: K.M. Litts, None; M. Okada, Allergan, Bayer; T.F.C. Heeren, 
      Heidelberg Engineering (S); A. Kalitzeos, None; V. Rocco, None; R.R. Mastey, 
      None; N. Singh, None; T. Kane, None; M. Kasilian, None; M. Fruttiger, None; M. 
      Michaelides, None; J. Carroll, None; C. Egan, Heidelberg Engineering (R), 
      Novartis (F), Haag-Streit (R)
EDAT- 2020/08/21 06:00
MHDA- 2020/08/21 06:01
PMCR- 2020/03/30
CRDT- 2020/08/21 06:00
PHST- 2019/09/18 00:00 [received]
PHST- 2020/01/13 00:00 [accepted]
PHST- 2020/08/21 06:00 [entrez]
PHST- 2020/08/21 06:00 [pubmed]
PHST- 2020/08/21 06:01 [medline]
PHST- 2020/03/30 00:00 [pmc-release]
AID - TVST-19-1928 [pii]
AID - 10.1167/tvst.9.4.27 [doi]
PST - epublish
SO  - Transl Vis Sci Technol. 2020 Mar 30;9(4):27. doi: 10.1167/tvst.9.4.27. 
      eCollection 2020 Mar.