PMID- 32818479
OWN - NLM
STAT- MEDLINE
DCOM- 20210311
LR  - 20210311
IS  - 1090-2422 (Electronic)
IS  - 0014-4827 (Linking)
VI  - 396
IP  - 1
DP  - 2020 Nov 1
TI  - Some like it translated: small ORFs in the 5'UTR.
PG  - 112229
LID - S0014-4827(20)30478-X [pii]
LID - 10.1016/j.yexcr.2020.112229 [doi]
AB  - The 5' untranslated region (5'UTR) is critical in determining 
      post-transcriptional control, which is partly mediated by short upstream open 
      reading frames (uORFs) present in half of mammalian transcripts. uORFs are 
      generally considered to provide functionally important repression of the main-ORF 
      by engaging initiating ribosomes, but under specific environmental conditions 
      such as cellular stress, uORFs can become essential to activate the translation 
      of the main coding sequence. In addition, a growing number of uORF-encoded 
      bioactive microproteins have been described, which have the potential to 
      significantly increase cellular protein diversity. Here we review the diverse 
      cellular contexts in which uORFs play a critical role and discuss the molecular 
      mechanisms underlying their function and regulation. The progress over the last 
      decades in dissecting uORF function suggests that the 5'UTR remains an exciting 
      frontier towards understanding how the cellular proteome is shaped in health and 
      disease.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Renz, Peter F
AU  - Renz PF
AD  - Institute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 
      CH-8952 Schlieren, Switzerland.
FAU - Valdivia-Francia, Fabiola
AU  - Valdivia-Francia F
AD  - Institute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 
      CH-8952 Schlieren, Switzerland; Life Science Zurich Graduate School, Molecular 
      Life Science Program, University of Zurich/ ETH Zurich, Switzerland.
FAU - Sendoel, Ataman
AU  - Sendoel A
AD  - Institute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 
      CH-8952 Schlieren, Switzerland. Electronic address: ataman.sendoel@uzh.ch.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200817
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (5' Untranslated Regions)
RN  - 0 (ATF4 protein, human)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (Eukaryotic Initiation Factors)
RN  - 0 (GCN4 protein, S cerevisiae)
RN  - 0 (RNA, Messenger)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 145891-90-3 (Activating Transcription Factor 4)
SB  - IM
MH  - *5' Untranslated Regions
MH  - Activating Transcription Factor 4/genetics/metabolism
MH  - Animals
MH  - Basic-Leucine Zipper Transcription Factors/genetics/metabolism
MH  - Eukaryotic Initiation Factors/*genetics/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - *Open Reading Frames
MH  - Polymorphism, Genetic
MH  - *Protein Biosynthesis
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Ribosomes/*genetics/metabolism
MH  - Saccharomyces cerevisiae/genetics/metabolism
MH  - Saccharomyces cerevisiae Proteins/genetics/metabolism
OTO - NOTNLM
OT  - 5'UTR
OT  - Development and Disease
OT  - Gene expression regulation
OT  - Translational regulation
OT  - uORFs
EDAT- 2020/08/21 06:00
MHDA- 2021/03/12 06:00
CRDT- 2020/08/21 06:00
PHST- 2020/01/09 00:00 [received]
PHST- 2020/07/28 00:00 [revised]
PHST- 2020/08/07 00:00 [accepted]
PHST- 2020/08/21 06:00 [pubmed]
PHST- 2021/03/12 06:00 [medline]
PHST- 2020/08/21 06:00 [entrez]
AID - S0014-4827(20)30478-X [pii]
AID - 10.1016/j.yexcr.2020.112229 [doi]
PST - ppublish
SO  - Exp Cell Res. 2020 Nov 1;396(1):112229. doi: 10.1016/j.yexcr.2020.112229. Epub 
      2020 Aug 17.