PMID- 32819261
OWN - NLM
STAT- MEDLINE
DCOM- 20211026
LR  - 20211026
IS  - 1573-4056 (Electronic)
VI  - 17
IP  - 2
DP  - 2021
TI  - Non-surgical Treatments for Lung Metastases in Patients with Soft Tissue Sarcoma: 
      Stereotactic Body Radiation Therapy (SBRT) and Radiofrequency Ablation (RFA).
PG  - 261-275
LID - 10.2174/1573405616999200819165709 [doi]
AB  - BACKGROUND: Radio-frequency ablation (RFA) and Stereotactic Body Radiation 
      Therapy (SBRT) are two emerging therapies for lung metastases. INTRODUCTION: 
      Aliterature review was performed to evaluate the outcomes and complications of 
      these procedures in patients with lung metastases from soft tissue sarcoma (STS). 
      METHODS: After selection, seven studies were included for each treatment 
      encompassing a total of 424 patients: 218 in the SBRT group and 206 in the RFA 
      group. RESULTS: The mean age ranged from 47.9 to 64 years in the SBRT group and 
      from 48 to 62.7 years in the RFA group. The most common histologic subtype was, 
      in both groups, leiomyosarcoma. In the SBRT group, median overall survival ranged 
      from 25.2 to 69 months and median disease- free interval was from 8.4 to 45 
      months. Two out of seven studies reported G3 and one G3 toxicity, respectively. 
      In RFA patients, overall survival ranged from 15 to 50 months. The most frequent 
      complication was pneumothorax. Local control showed a high percentage for both 
      procedures. CONCLUSION: SBRT is recommended in patients unsuitable to surgery, in 
      synchronous bilateral pulmonary metastases, in case of deep lesions and patients 
      receiving high-risk systemic therapies. RFA is indicated in case of a long 
      disease-free interval, in oligometastatic disease, when only the lung is 
      involved, in small size lesions far from large vessels. Further large randomized 
      studies are necessary to establish whether these treatments may also represent a 
      reliable alternative to surgery.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Tetta, Cecilia
AU  - Tetta C
AD  - Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, 
      Bologna, Italy.
FAU - Carpenzano, Maria
AU  - Carpenzano M
AD  - Cardiovascular Research Institute Maastricht - CARIM, Maastricht University 
      Medical Center, Maastricht, Netherlands.
FAU - Algargoush, Areej T J
AU  - Algargoush ATJ
AD  - Cardiovascular Research Institute Maastricht - CARIM, Maastricht University 
      Medical Center, Maastricht, Netherlands.
FAU - Algargoosh, Marwah
AU  - Algargoosh M
AD  - Cardiovascular Research Institute Maastricht - CARIM, Maastricht University 
      Medical Center, Maastricht, Netherlands.
FAU - Londero, Francesco
AU  - Londero F
AD  - Cardiovascular Research Institute Maastricht - CARIM, Maastricht University 
      Medical Center, Maastricht, Netherlands.
FAU - Maessen, Jos G
AU  - Maessen JG
AD  - Cardiovascular Research Institute Maastricht - CARIM, Maastricht University 
      Medical Center, Maastricht, Netherlands.
FAU - Gelsomino, Sandro
AU  - Gelsomino S
AD  - Cardiovascular Research Institute Maastricht - CARIM, Maastricht University 
      Medical Center, Maastricht, Netherlands.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Med Imaging
JT  - Current medical imaging
JID - 101762461
SB  - IM
MH  - Humans
MH  - *Lung Neoplasms/radiotherapy
MH  - Middle Aged
MH  - *Radiofrequency Ablation/adverse effects
MH  - *Radiosurgery/adverse effects
MH  - *Sarcoma/radiotherapy
MH  - *Soft Tissue Neoplasms
OTO - NOTNLM
OT  - RFA
OT  - SBRT
OT  - Soft tissue sarcoma
OT  - leiomyosarcoma
OT  - lung metastases
OT  - randomized studies
EDAT- 2020/08/21 06:00
MHDA- 2021/10/27 06:00
CRDT- 2020/08/22 06:00
PHST- 2020/03/10 00:00 [received]
PHST- 2020/06/04 00:00 [revised]
PHST- 2020/06/16 00:00 [accepted]
PHST- 2020/08/21 06:00 [pubmed]
PHST- 2021/10/27 06:00 [medline]
PHST- 2020/08/22 06:00 [entrez]
AID - CMIR-EPUB-109332 [pii]
AID - 10.2174/1573405616999200819165709 [doi]
PST - ppublish
SO  - Curr Med Imaging. 2021;17(2):261-275. doi: 10.2174/1573405616999200819165709.