PMID- 32820327
OWN - NLM
STAT- MEDLINE
DCOM- 20220110
LR  - 20240226
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 31
IP  - 1
DP  - 2021 Jan 1
TI  - Suppressing Anterior Cingulate Cortex Modulates Default Mode Network and Behavior 
      in Awake Rats.
PG  - 312-323
LID - 10.1093/cercor/bhaa227 [doi]
AB  - The default mode network (DMN) is a principal brain network in the mammalian 
      brain. Although the DMN in humans has been extensively studied with respect to 
      network structure, function, and clinical implications, our knowledge of DMN in 
      animals remains limited. In particular, the functional role of DMN nodes, and how 
      DMN organization relates to DMN-relevant behavior are still elusive. Here we 
      investigated the causal relationship of inactivating a pivotal node of DMN (i.e., 
      dorsal anterior cingulate cortex [dACC]) on DMN function, network organization, 
      and behavior by combining chemogenetics, resting-state functional magnetic 
      resonance imaging (rsfMRI) and behavioral tests in awake rodents. We found that 
      suppressing dACC activity profoundly changed the activity and connectivity of 
      DMN, and these changes were associated with altered DMN-related behavior in 
      animals. The chemo-rsfMRI-behavior approach opens an avenue to mechanistically 
      dissecting the relationships between a specific node, brain network function, and 
      behavior. Our data suggest that, like in humans, DMN in rodents is a functional 
      network with coordinated activity that mediates behavior.
CI  - (c) The Author(s) 2020. Published by Oxford University Press. All rights reserved. 
      For permissions, please e-mail: journals.permissions@oup.com.
FAU - Tu, Wenyu
AU  - Tu W
AD  - Neuroscience Program, The Huck Institutes of the Life Sciences, The Pennsylvania 
      State University, University Park, PA 16802, USA.
FAU - Ma, Zilu
AU  - Ma Z
AD  - Department of Biomedical Engineering, The Pennsylvania State University, 
      University Park, PA 16802, USA.
FAU - Ma, Yuncong
AU  - Ma Y
AD  - Department of Biomedical Engineering, The Pennsylvania State University, 
      University Park, PA 16802, USA.
FAU - Dopfel, David
AU  - Dopfel D
AD  - Department of Biomedical Engineering, The Pennsylvania State University, 
      University Park, PA 16802, USA.
FAU - Zhang, Nanyin
AU  - Zhang N
AD  - Neuroscience Program, The Huck Institutes of the Life Sciences, The Pennsylvania 
      State University, University Park, PA 16802, USA.
AD  - Department of Biomedical Engineering, The Pennsylvania State University, 
      University Park, PA 16802, USA.
LA  - eng
GR  - R01 NS085200/NS/NINDS NIH HHS/United States
GR  - RF1 MH114224/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Brain/physiopathology
MH  - Brain Mapping/methods
MH  - Gyrus Cinguli/*physiopathology
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Nerve Net/*physiopathology
MH  - Rats, Long-Evans
MH  - Wakefulness/*physiology
MH  - Rats
PMC - PMC7727348
OTO - NOTNLM
OT  - DREADD
OT  - awake
OT  - default mode network
OT  - rat
OT  - resting-state fMRI
EDAT- 2020/08/21 06:00
MHDA- 2022/01/11 06:00
PMCR- 2021/08/20
CRDT- 2020/08/22 06:00
PHST- 2020/04/13 00:00 [received]
PHST- 2020/06/30 00:00 [revised]
PHST- 2020/07/26 00:00 [accepted]
PHST- 2020/08/21 06:00 [pubmed]
PHST- 2022/01/11 06:00 [medline]
PHST- 2020/08/22 06:00 [entrez]
PHST- 2021/08/20 00:00 [pmc-release]
AID - 5894990 [pii]
AID - bhaa227 [pii]
AID - 10.1093/cercor/bhaa227 [doi]
PST - ppublish
SO  - Cereb Cortex. 2021 Jan 1;31(1):312-323. doi: 10.1093/cercor/bhaa227.