PMID- 32820755
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20201028
LR  - 20201028
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 145
IP  - 21
DP  - 2020 Oct 26
TI  - Chemically robust succinimide-group-assisted irreversible bonding of 
      poly(dimethylsiloxane)-thermoplastic microfluidic devices at room temperature.
PG  - 6887-6894
LID - 10.1039/d0an01268h [doi]
AB  - This study investigates surface chemical modification using anhydride silane and 
      amino silane reagents at room temperature (RT) to realize bonding between 
      silicon-based PDMS and non-silicon thermoplastics. The anhydride silane shows 
      vigorous activity against water, forming a terminal dicarboxylic acid in the 
      plasma-activated elastomeric poly(dimethylsiloxane) (PDMS) surface, and it can 
      readily react with amino-silane-modified thermoplastic surfaces, resulting in a 
      permanent bond via the formation of a stable succinimide group without the 
      requirement for high temperature or additional pressure to initiate the bonding. 
      The modified surfaces of PDMS and thermoplastics were successfully characterized 
      by water contact angle measurement, fluorescence measurement, X-ray photoelectron 
      spectroscopy (XPS), and atomic force microscopy (AFM). The bond strength values 
      of PDMS-thermoplastic assemblies, measured by the tensile test for 
      PDMS-polystyrene (PS), PDMS-poly(methyl methacrylate) (PMMA), PDMS-polycarbonate 
      (PC), and PDMS-poly(ethyl terephthalate) (PET) assemblies, were found to be 
      approximately 519.5 +/- 6, 259 +/- 15, 476.6 +/- 8, and 458.2 +/- 27 kPa, respectively. 
      Moreover, the bond strength was further examined by performing a burst test for 
      PDMS-PMMA, PDMS-PS, PDMS-PC, and PDMS-PET microfluidic devices, which were found 
      to have the maximum pressure values at approximately 344.73, 448.15, 413.68, and 
      379.21 kPa, respectively. Based on these results, the hybrid microfluidic devices 
      can be used for high-pressure experiments such as blood plasma separation and 
      continuous-flow polymerase chain reaction (CF-PCR). We have also performed the 
      large area bonding of the PDMS-PC assembly (10 x 10 cm2), ensuring the high 
      robustness and reliability of the proposed surface chemical bonding method.
FAU - Sivakumar, Rajamanickam
AU  - Sivakumar R
AD  - Department of Industrial Environmental Engineering, College of Industrial 
      Environmental Engineering, Gachon University, 1342 Seongnam-daero, Sujeong-gu, 
      Seongnam-si, Gyeonggi-do 13120, Korea.
FAU - Lee, Nae Yoon
AU  - Lee NY
LA  - eng
PT  - Journal Article
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
SB  - IM
EDAT- 2020/08/22 06:00
MHDA- 2020/08/22 06:01
CRDT- 2020/08/22 06:00
PHST- 2020/08/22 06:00 [pubmed]
PHST- 2020/08/22 06:01 [medline]
PHST- 2020/08/22 06:00 [entrez]
AID - 10.1039/d0an01268h [doi]
PST - ppublish
SO  - Analyst. 2020 Oct 26;145(21):6887-6894. doi: 10.1039/d0an01268h.