PMID- 32821162
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 1179-1322 (Print)
IS  - 1179-1322 (Electronic)
IS  - 1179-1322 (Linking)
VI  - 12
DP  - 2020
TI  - Silenced Myeloblastosis Protein Suppresses Oral Tongue Squamous Cell Carcinoma 
      via the microRNA-130a/Cylindromatosis Axis.
PG  - 6935-6946
LID - 10.2147/CMAR.S252340 [doi]
AB  - BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) represents oral 
      epithelial cell damage. Myeloblastosis (MYB) is involved in OTSCC. This study 
      tried to probe roles of MYB in OSCC with potential axis. METHODS: Expression of 
      MYB and miR-130a in OTSCC was detected. Western blot analysis was utilized to 
      determine epithelial-mesenchymal transition-related protein levels. 
      Dual-luciferase reporter gene assay certified the target relation between 
      miR-130a and CYLD. Moreover, xenograft tumors in nude mice were applied to 
      confirm the in vitro experiments. RESULTS: Both MYB and miR-130a were highly 
      expressed in OTSCC, which promoted cell growth. Meanwhile, silenced miR-130a 
      discouraged cell development enhanced by overexpressed MYB. CYLD was poorly 
      expressed in OTSCC and targeted by miR-130a. Additionally, MYB knockdown 
      activated CYLD to suppress OTSCC by downregulating miR-130a. CONCLUSION: Our 
      experiment supported that silenced MYB suppressed OTSCC malignancy by inhibiting 
      miR-130a and activating CYLD. This investigation may provide novel insights for 
      OTSCC treatment.
CI  - (c) 2020 Yang et al.
FAU - Yang, Ran
AU  - Yang R
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, Chengdu 610041, Sichuan, People's Republic of China.
FAU - Shui, Yusen
AU  - Shui Y
AD  - Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan 
      University, Chengdu 610041, Sichuan, People's Republic of China.
FAU - Hu, Shoushan
AU  - Hu S
AD  - Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan 
      University, Chengdu 610041, Sichuan, People's Republic of China.
FAU - Zhang, Kun
AU  - Zhang K
AD  - Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan 
      University, Chengdu 610041, Sichuan, People's Republic of China.
FAU - Wang, Yuru
AU  - Wang Y
AD  - Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan 
      University, Chengdu 610041, Sichuan, People's Republic of China.
FAU - Peng, Yiran
AU  - Peng Y
AUID- ORCID: 0000-0002-3110-4465
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, Chengdu 610041, Sichuan, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20200805
PL  - New Zealand
TA  - Cancer Manag Res
JT  - Cancer management and research
JID - 101512700
RIN - Cancer Manag Res. 2021 Oct 26;13:8059-8060. PMID: 34729024
PMC - PMC7425089
OTO - NOTNLM
OT  - CYLD
OT  - MYB
OT  - epithelial-mesenchymal transition
OT  - microRNA-130a
OT  - oral tongue squamous cell carcinoma
OT  - proliferation
COIS- The authors declared that they have no competing interests.
EDAT- 2020/08/22 06:00
MHDA- 2020/08/22 06:01
PMCR- 2020/08/05
CRDT- 2020/08/22 06:00
PHST- 2020/03/03 00:00 [received]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/08/22 06:00 [entrez]
PHST- 2020/08/22 06:00 [pubmed]
PHST- 2020/08/22 06:01 [medline]
PHST- 2020/08/05 00:00 [pmc-release]
AID - 252340 [pii]
AID - 10.2147/CMAR.S252340 [doi]
PST - epublish
SO  - Cancer Manag Res. 2020 Aug 5;12:6935-6946. doi: 10.2147/CMAR.S252340. eCollection 
      2020.