PMID- 32821446
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 2149-2042 (Print)
IS  - 2149-4606 (Electronic)
IS  - 2149-4606 (Linking)
VI  - 34
IP  - 3
DP  - 2019
TI  - Effects of Three Different Frequencies of Aerobic Physical Activity on Heart and 
      Kidney Tissues in Type 2 Diabetes-Induced Rats.
PG  - 252-262
LID - 10.5222/MMJ.2019.28009 [doi]
AB  - OBJECTIVE: Exercise has many beneficial effects in the treatment and prevention 
      of Type 2 Diabetes Mellitus (T2DM). The aim of this study was to evaluate the 
      effect of physical activities with different frequencies performed within a total 
      total duration of one week on the heart and kidney tissues and vascular 
      endothelial growth factor (VEGF) expressions in experimental T2DM model. METHOD: 
      Rats (n: 30) were divided into sedentary control (SC), sedentary T2DM (SD), T2DM 
      and continuous exercise (DEc, 30 min/day, 5 days/week), T2DM and short bouts 
      exercise (DEsb, 3x10 min/day, 5 days/week), T2DM and weekend warrior exercise 
      (DEww, 35+40 min/day, 2 days/week) groups. Rats were administered streptozotocin 
      (65 mg/kg) and nicotinamide (110 mg/kg) through intraperitoneal route. After 
      6-weeks of swimming exercise (total duration 150 min/week), biochemical analyzes 
      were performed to measure oral glucose tolerance test, insulin sensitivity and 
      cytokines. Histopathological and immunohistochemical analyses [VEGF, capillary 
      density, Transforming growth factor beta (TGF-beta)] were performed in heart and 
      kidney tissues. RESULTS: Compared with sedentary T2DM rats, significant 
      improvements were observed in all exercise groups in terms of blood glucose 
      level, insulin sensitivity, capillary density in heart tissue, VEGF expressions 
      in tissues, TGF-beta expressions in kidney tissue and all histopathological analysis 
      (p<0.05). CONCLUSION: This study shows that physical activity at various 
      frequencies may significantly ameliorate harmful effects of T2DM on heart and 
      kidney tissue without significant differences between exercise frequencies, 
      provided that the total duration of aerobic exercise remains the same (150 
      min/week).
CI  - Copyright Istanbul Medeniyet University Faculty of Medicine.
FAU - Alaca, Nuray
AU  - Alaca N
AUID- ORCID: 0000-0003-3034-9388
AD  - Acibadem Mehmet Ali Aydinlar University, Department of Physiotherapy and 
      Rehabilitation, Faculty of Health Sciences, Istanbul, Turkey.
FAU - Uslu, Serap
AU  - Uslu S
AUID- ORCID: 0000-0002-6613-527X
AD  - Istanbul Medeniyet University, Department of Histology and Embryology, School of 
      Medicine, Istanbul, Turkey.
FAU - Basdemir, Gulcin
AU  - Basdemir G
AUID- ORCID: 0000-0002-2104-8957
AD  - Okan University, Department of Pathology, School of Medicine, Istanbul, Turkey.
FAU - Gulec Suyen, Guldal
AU  - Gulec Suyen G
AUID- ORCID: 0000-0003-0863-1547
AD  - Acibadem Mehmet Ali Aydinlar University, Department of Physiology, School of 
      Medicine, Istanbul, Turkey.
FAU - Ozbeyli, Dilek
AU  - Ozbeyli D
AUID- ORCID: 0000-0002-4141-6913
AD  - Marmara University, Department of Pathology Laboratory Techniques, Vocational 
      School of Health Services, Istanbul, Turkey.
FAU - Kurtel, Hizir
AU  - Kurtel H
AUID- ORCID: 0000-0003-3633-7863
AD  - Marmara University, Department of Physiology, School of Medicine, Istanbul, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190927
PL  - Turkey
TA  - Medeni Med J
JT  - Medeniyet medical journal
JID - 101676811
PMC - PMC7433736
OTO - NOTNLM
OT  - Physical activity
OT  - short bouts of exercise
OT  - type 2 diabetes mellitus
OT  - vascular endothelial growth factor
OT  - weekend warrior
COIS- Conflict of interest: One of the authors of this article is an Editorial Board 
      Member of this journal and was excluded from all evaluation steps. The other 
      authors declare that they have no conflict of interest.
EDAT- 2019/01/01 00:00
MHDA- 2019/01/01 00:01
PMCR- 2019/09/27
CRDT- 2020/08/22 06:00
PHST- 2019/07/10 00:00 [received]
PHST- 2019/09/05 00:00 [accepted]
PHST- 2020/08/22 06:00 [entrez]
PHST- 2019/01/01 00:00 [pubmed]
PHST- 2019/01/01 00:01 [medline]
PHST- 2019/09/27 00:00 [pmc-release]
AID - 10.5222/MMJ.2019.28009 [doi]
PST - ppublish
SO  - Medeni Med J. 2019;34(3):252-262. doi: 10.5222/MMJ.2019.28009. Epub 2019 Sep 27.