PMID- 32823415
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20220416
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 68
IP  - 9
DP  - 2020 Sep
TI  - Anti-inflammatory effect of cortistatin in rat endotoxin-induced uveitis model.
PG  - 1920-1924
LID - 10.4103/ijo.IJO_290_20 [doi]
AB  - PURPOSE: To evaluate the anti-inflammatory effect of cortistatin (CST) in 
      endotoxin-induced uveitis (EIU) model and to compare the results with 
      corticosteroid treatment. METHODS: A total of 35 healthy Wistar albino rats were 
      randomly divided into five groups. EIU was induced by a single subcutaneous 
      injection of lipopolysaccharide (LPS). Group I received intraperitoneal (ip) 
      normal saline (NS), Group II received ip 150 mug LPS plus NS, Group III received 
      ip 150 mug LPS plus 250 mug/kg CST, Group IV received ip 150 mug LPS plus 1mg/kg 
      dexamethasone, and Group V received ip 250 mug/kg CST only. The aqueous humor was 
      collected 24 h after injection and the infiltrating cells were determined. 
      Moreover, histopathological and immunohistochemical examinations were also 
      performed. RESULTS: The clinical score and infiltrated cell count were reduced in 
      Groups III and IV compared with Group II (P < 0.001). The pathological findings 
      of Groups III and IV were significantly reduced compared with Group II (P < 
      0.001). These findings were similar between Groups III and IV (P = 1.000). Tumor 
      necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) immunoreactivity in 
      the ciliary body of Group III and Group IV were significantly reduced compared 
      with Group II (P < 0.001). TNF-alpha and IL-1beta immunoreactivity in the ciliary body 
      of Group III and Group IV were similar compared with Group I and Group V (range 
      of P values was 0.539-0.958). CONCLUSION: CST administration as a therapeutic 
      agent might ameliorate the severity of intraocular inflammation in uveitis 
      patients. In conclusion, effect of CST and dexamethasone in EIU model was 
      comparable.
FAU - Balbaba, Mehmet
AU  - Balbaba M
AD  - Department of Ophthalmology; Faculty of Medicine, Firat University, Elazig, 
      Turkey.
FAU - Dal, Ali
AU  - Dal A
AD  - Department of Ophthalmology; Faculty of Medicine, Firat University, Elazig, 
      Turkey.
FAU - Colakoglu, Neriman
AU  - Colakoglu N
AD  - Faculty of Medicine; Histology-Embryology, Firat University, Elazig, Turkey.
FAU - Bulmus, Ozgur
AU  - Bulmus O
AD  - Physiology; Health Sciences, Firat University, Elazig, Turkey.
FAU - Ulas, Fatih
AU  - Ulas F
AD  - Department of Ophthalmology, Faculty of Medicine, Abant Izzet Baysal University, 
      Bolu, Turkey.
FAU - Yildirim, Hakan
AU  - Yildirim H
AD  - Department of Ophthalmology; Faculty of Medicine, Firat University, Elazig, 
      Turkey.
FAU - Aydemir, Orhan
AU  - Aydemir O
AD  - Department of Ophthalmology; Faculty of Medicine, Firat University, Elazig, 
      Turkey.
FAU - Eroksuz, Yesari
AU  - Eroksuz Y
AD  - Faculty of Medicine; Veterinary Medicine, Firat University, Elazig, Turkey.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Endotoxins)
RN  - 0 (Neuropeptides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (cortistatin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Aqueous Humor
MH  - Disease Models, Animal
MH  - *Endotoxins
MH  - Humans
MH  - Neuropeptides
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha
MH  - *Uveitis/chemically induced/drug therapy
PMC - PMC7690532
OTO - NOTNLM
OT  - Cortistatin
OT  - endotoxin-induced uveitis
OT  - interleukin-1
OT  - tumor necrosis factor-alpha
COIS- None
EDAT- 2020/08/23 06:00
MHDA- 2021/05/15 06:00
PMCR- 2020/09/01
CRDT- 2020/08/23 06:00
PHST- 2020/08/23 06:00 [entrez]
PHST- 2020/08/23 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2020_68_9_1920_292565 [pii]
AID - IJO-68-1920 [pii]
AID - 10.4103/ijo.IJO_290_20 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2020 Sep;68(9):1920-1924. doi: 10.4103/ijo.IJO_290_20.