PMID- 32825099
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201020
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 10
IP  - 9
DP  - 2020 Aug 19
TI  - The Maternal Diet with Fish Oil Might Decrease the Oxidative Stress and 
      Inflammatory Response in Sows, but Increase the Susceptibility to Inflammatory 
      Stimulation in their Offspring.
LID - 10.3390/ani10091455 [doi]
LID - 1455
AB  - The aim of this study is to investigate the effect of the maternal diet with fish 
      oil on the oxidative stress and inflammatory response in sows, and the protective 
      effect on the piglets suckling the sows fed the diet with fish oil in the context 
      of inflammatory stimulation. Twelve sows were divided into two groups. Sows were 
      fed soybean oil diet (SD) or soybean oil + fish oil diet (FD) from gestation to 
      lactation period. The blood samples of sows were collected from the auricular 
      vein at the 16th day of lactation. One piglet was selected from each litter on 
      the 14th day after birth. Lipopolysaccharide (LPS) was injected into the neck 
      muscle after pre-treatment blood samples were collected from the anterior vena 
      cava of piglets. The blood samples of piglets were collected at 5 h and 48 h 
      post-LPS injection from the front cavity vein. Liver samples were collected at 48 
      h post-LPS injection. The FD diet significantly increased the level of 
      high-density lipoprotein cholesterol (HDL-C) in the plasma of lactating sow, 
      decreased the levels of alkaline phosphatase(AKP) and tumor necrosis factor 
      alpha(TNF-alpha) in the plasma of lactating sows, and increased the level of 
      immunoglobulin G(IgG) in the colostrum and interleukin-10(IL-10) in the milk (p < 
      0.05). In the FD group, the levels of glutathione peroxidase (GSH-Px) and total 
      antioxidant capacity (T-AOC) significantly increased in the plasma of piglets at 
      48 h post-LPS injection (p < 0.05). Meanwhile, the relative expression of GSH-Px 
      mRNA was decreased in the FD group (p < 0.05). However, the levels of 
      interleukin-1 beta (IL-1beta) and interleukin-6(IL-6) in the plasma of piglets were 
      significantly higher in the FD group pre- and post-LPS injection (p < 0.05). The 
      ratio of the phosphonated extracellular regulated protein kinases to the 
      extracellular regulated protein kinases (p-ERK/ERK) protein in the livers of 
      piglets was decreased (p < 0.05), but the expression of nuclear transcription 
      factor-kappaB (NF-kappaB) mRNA and the ratio of the phosphonated inhibitor of NF-kappaB to 
      the inhibitor of NF-kappaB (p-IkappaB-alpha/IkappaB-alpha) protein was increased in the livers of 
      piglets (p < 0.05). These results indicate that a maternal diet with fish oil 
      might decrease the oxidative stress and inflammatory response in sows, and 
      enhance the antioxidative ability but increase the susceptibility to inflammatory 
      stimulation in their progenies.
FAU - Luo, Wenli
AU  - Luo W
AD  - Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and 
      Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
FAU - Xu, Weina
AU  - Xu W
AD  - Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and 
      Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
FAU - Zhang, Jing
AU  - Zhang J
AD  - Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and 
      Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
FAU - Yao, Jianbo
AU  - Yao J
AD  - Division of Animal and Nutritional Sciences, West Virginia University, 
      Morgantown, WV 26506, USA.
FAU - Xu, Jianxiong
AU  - Xu J
AD  - Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and 
      Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
LA  - eng
PT  - Journal Article
DEP - 20200819
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC7552684
OTO - NOTNLM
OT  - LPS
OT  - ROS
OT  - cytokine
OT  - liver
OT  - sow-reared piglet
COIS- The authors declare no conflict of interest.
EDAT- 2020/08/23 06:00
MHDA- 2020/08/23 06:01
PMCR- 2020/08/19
CRDT- 2020/08/23 06:00
PHST- 2020/08/01 00:00 [received]
PHST- 2020/08/17 00:00 [revised]
PHST- 2020/08/17 00:00 [accepted]
PHST- 2020/08/23 06:00 [entrez]
PHST- 2020/08/23 06:00 [pubmed]
PHST- 2020/08/23 06:01 [medline]
PHST- 2020/08/19 00:00 [pmc-release]
AID - ani10091455 [pii]
AID - animals-10-01455 [pii]
AID - 10.3390/ani10091455 [doi]
PST - epublish
SO  - Animals (Basel). 2020 Aug 19;10(9):1455. doi: 10.3390/ani10091455.