PMID- 32825180
OWN - NLM
STAT- MEDLINE
DCOM- 20210216
LR  - 20210216
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 17
DP  - 2020 Aug 19
TI  - Pharmacogenomics of Antibiotics.
LID - 10.3390/ijms21175975 [doi]
LID - 5975
AB  - Although the introduction of antibiotics in medicine has resulted in one of the 
      most successful events and in a major breakthrough to reduce morbidity and 
      mortality caused by infectious disease, response to these agents is not always 
      predictable, leading to differences in their efficacy, and sometimes to the 
      occurrence of adverse effects. Genetic variability, resulting in differences in 
      the pharmacokinetics and pharmacodynamics of antibiotics, is often involved in 
      the variable response, of particular importance are polymorphisms in genes 
      encoding for drug metabolizing enzymes and membrane transporters. In addition, 
      variations in the human leukocyte antigen (HLA) class I and class II genes have 
      been associated with different immune mediated reactions induced by antibiotics. 
      In recent years, the importance of pharmacogenetics in the personalization of 
      therapies has been recognized in various clinical fields, although not clearly in 
      the context of antibiotic therapy. In this review, we make an overview of 
      antibiotic pharmacogenomics and of its potential role in optimizing drug therapy 
      and reducing adverse reactions.
FAU - Stocco, Gabriele
AU  - Stocco G
AUID- ORCID: 0000-0003-0964-5879
AD  - Department of Life Sciences, University of Trieste, I-34128 Trieste, Italy.
FAU - Lucafo, Marianna
AU  - Lucafo M
AUID- ORCID: 0000-0003-1355-3782
AD  - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", I-34137 Trieste, 
      Italy.
FAU - Decorti, Giuliana
AU  - Decorti G
AUID- ORCID: 0000-0002-9714-6246
AD  - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", I-34137 Trieste, 
      Italy.
AD  - Department of Medicine, Surgery and Health Sciences, University of Trieste, 
      I-34149 Trieste, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200819
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Anti-Bacterial Agents/adverse effects/pharmacokinetics/*therapeutic use
MH  - Bacterial Infections/drug therapy/*genetics
MH  - Genome-Wide Association Study/methods
MH  - HLA Antigens/genetics
MH  - Humans
MH  - *Pharmacogenomic Variants
MH  - Precision Medicine/methods
PMC - PMC7504675
OTO - NOTNLM
OT  - adverse drug reaction
OT  - antibiotics
OT  - human leukocyte antigen (HLA)
OT  - pharmacogenomics
OT  - pharmacokinetics
OT  - transporters
COIS- The authors declare no conflict of interest.
EDAT- 2020/08/23 06:00
MHDA- 2021/02/17 06:00
PMCR- 2020/09/01
CRDT- 2020/08/23 06:00
PHST- 2020/07/28 00:00 [received]
PHST- 2020/08/12 00:00 [revised]
PHST- 2020/08/17 00:00 [accepted]
PHST- 2020/08/23 06:00 [entrez]
PHST- 2020/08/23 06:00 [pubmed]
PHST- 2021/02/17 06:00 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - ijms21175975 [pii]
AID - ijms-21-05975 [pii]
AID - 10.3390/ijms21175975 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Aug 19;21(17):5975. doi: 10.3390/ijms21175975.