PMID- 32825345
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201028
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 9
DP  - 2020 Aug 20
TI  - Early Valve Replacement for Severe Aortic Valve Disease: Effect on Mortality and 
      Clinical Ramifications.
LID - 10.3390/jcm9092694 [doi]
LID - 2694
AB  - Timing of aortic valve intervention for chronic aortic regurgitation (AR) and/or 
      aortic stenosis (AS) potentially affects long-term survival. The 2014 American 
      Heart Association/American College of Cardiology (AHA/ACC) guidelines provide 
      recommendations for the timing of intervention. Subsequent to the guidelines' 
      release, several studies have been published that suggest a survival benefit from 
      earlier timing of surgery for severe AR and/or AS. The aim of this review was to 
      determine whether patients who have chronic aortic regurgitation (AR) and/or 
      aortic stenosis (AS) have a survival benefit from earlier timing of aortic valve 
      surgery. Medical databases were systematically searched from January 2015 to 
      April 2020 for randomized controlled trials (RCTs) and observational studies that 
      examined the timing of aortic valve replacement surgery for chronic AR and/or AS. 
      For chronic AR, four observational studies and no RCTs were identified. For 
      chronic AS, five observational studies, one RCT and one meta-analysis were 
      identified. One observational study examining mixed aortic valve disease (MAVD) 
      was identified. All of these studies, for AR, AS, and MAVD, found long-term 
      survival benefit from timing of aortic valve surgery earlier than the current 
      guidelines. Larger prospective RCTs are required to evaluate the benefit of 
      earlier surgical intervention.
FAU - Koerber, Jason P
AU  - Koerber JP
AD  - Department of Anaesthesia, Flinders Medical Centre, Adelaide, SA 5042, Australia.
FAU - Bennetts, Jayme S
AU  - Bennetts JS
AD  - Department of Cardiac and Thoracic Surgery, Flinders Medical Centre, Adelaide, SA 
      5042, Australia.
AD  - College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, 
      Australia.
FAU - Psaltis, Peter J
AU  - Psaltis PJ
AD  - Adelaide Medical School, Faculty of Health and Medical Sciences, University of 
      Adelaide, Adelaide, SA 5000, Australia.
AD  - Vascular Research Centre, Lifelong Health Theme, South Australian Health and 
      Medical Research Institute, Adelaide, SA 5000, Australia.
AD  - Department of Cardiology, Central Adelaide Local Health Network, Adelaide, SA 
      5000, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200820
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7563468
OTO - NOTNLM
OT  - aortic regurgitation
OT  - aortic stenosis
OT  - aortic valve replacement
OT  - mixed aortic valve disease
OT  - survival
OT  - transcatheter aortic valve implantation
OT  - valvular heart disease
COIS- P.J.P. receives a L2 Future Leader Fellowship from the National Heart Foundation 
      of Australia (FLF102056) and L2 Career Development Fellowship from the NHMRC 
      (CDF11615reproduce06). P.J.P. has received research support from Abbott Vascular, 
      consulting fees from Amgen and Esperion and travel or speaker honoraria from 
      AstraZeneca, Bayer, Boehringer Ingelheim, Merck Schering-Plough and Pfizer. 
      J.S.B. is an Advisor for Medtronic, Abbott Vascular, and Edwards Lifesciences and 
      has received travel, research, and/or speaking honoraria from Medtronic and 
      Edwards Lifesciences.
EDAT- 2020/08/23 06:00
MHDA- 2020/08/23 06:01
PMCR- 2020/08/20
CRDT- 2020/08/23 06:00
PHST- 2020/07/14 00:00 [received]
PHST- 2020/08/17 00:00 [revised]
PHST- 2020/08/18 00:00 [accepted]
PHST- 2020/08/23 06:00 [entrez]
PHST- 2020/08/23 06:00 [pubmed]
PHST- 2020/08/23 06:01 [medline]
PHST- 2020/08/20 00:00 [pmc-release]
AID - jcm9092694 [pii]
AID - jcm-09-02694 [pii]
AID - 10.3390/jcm9092694 [doi]
PST - epublish
SO  - J Clin Med. 2020 Aug 20;9(9):2694. doi: 10.3390/jcm9092694.