PMID- 32826223
OWN - NLM
STAT- MEDLINE
DCOM- 20210924
LR  - 20210924
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 105
IP  - 7
DP  - 2021 Jul
TI  - Evaluation of the clinical utility of optical coherence tomography angiography in 
      age-related macular degeneration.
PG  - 983-988
LID - 10.1136/bjophthalmol-2020-316622 [doi]
AB  - BACKGROUND/AIMS: To evaluate the ability of optical coherence tomography 
      angiography (OCTA) to identify the presence or absence of choroidal 
      neovascularisation (CNV) and CNV activity in age-related macular degeneration 
      (AMD). METHODS: Clinical parameters, fundus fluorescein angiogram and 
      spectral-domain optical coherence tomography (SD-OCT) were used as the gold 
      standard to determine disease activity. OCTA imaging was performed on the same 
      day and was graded by two masked retina specialists for the presence or absence 
      of CNV. Traditional multimodal imaging and OCTA findings were compared. RESULTS: 
      One hundred and fifty-two eyes of 106 patients with AMD were retrospectively 
      reviewed. Of these, 59 eyes had wet AMD and 93 had dry AMD with high-risk drusen. 
      OCTA had 85.4% and 79.3% specificity and sensitivity, respectively, in 
      determining the presence or absence of CNV. OCTA was 69.5% accurate in 
      determining active CNV. False positives and negatives were 21.6% and 8.0%, 
      respectively. CONCLUSIONS: This study suggests that en-face OCTA images allow a 
      moderate ability to identify CNV and that OCTA alone is weak at recognising 
      active CNV requiring treatment in AMD.
CI  - (c) Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Cavichini, Melina
AU  - Cavichini M
AD  - Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, 
      La Jolla, California, USA.
AD  - Ophthalmology, Faculdade De Medicina Do ABC, Santo Andre, Brazil.
FAU - Dans, Kunny C
AU  - Dans KC
AD  - Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, 
      La Jolla, California, USA.
FAU - Jhingan, Mahima
AU  - Jhingan M
AD  - Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, 
      La Jolla, California, USA.
AD  - Aravind Eye Hospital, Madurai, India.
FAU - Amador-Patarroyo, Manuel J
AU  - Amador-Patarroyo MJ
AD  - Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, 
      La Jolla, California, USA.
AD  - Ophthalmology, Escuela Superior De Oftalmologia, Instituto Barraquer De America, 
      Bogota, Colombia.
FAU - Borooah, Shyamanga
AU  - Borooah S
AD  - Ophthalmology, University of California San Diego, La Jolla, California, USA.
AD  - Center for Clinical Brain Sciences, School of Clinical Sciences, the University 
      of Edinburgh, Edinburgh, Scotland, UK.
FAU - Bartsch, Dirk-Uwe
AU  - Bartsch DU
AD  - Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, 
      La Jolla, California, USA.
FAU - Nudleman, Eric
AU  - Nudleman E
AD  - Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, 
      La Jolla, California, USA.
FAU - Freeman, William R
AU  - Freeman WR
AUID- ORCID: 0000-0001-9979-2500
AD  - Jacobs Retina Center, Shiley Eye, UCSD, La Jolla, California, USA 
      wrfreeman@health.ucsd.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200821
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroidal Neovascularization/*diagnosis
MH  - False Positive Reactions
MH  - Female
MH  - *Fluorescein Angiography
MH  - Geographic Atrophy/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Retinal Drusen/diagnosis
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity
MH  - Wet Macular Degeneration/*diagnosis
OTO - NOTNLM
OT  - Degeneration
OT  - Imaging
OT  - Macula
OT  - Neovascularisation
OT  - Retina
COIS- Competing interests: None declared.
EDAT- 2020/08/23 06:00
MHDA- 2021/09/25 06:00
CRDT- 2020/08/23 06:00
PHST- 2020/05/08 00:00 [received]
PHST- 2020/07/11 00:00 [accepted]
PHST- 2020/07/03 00:00 [revised]
PHST- 2020/08/23 06:00 [pubmed]
PHST- 2021/09/25 06:00 [medline]
PHST- 2020/08/23 06:00 [entrez]
AID - bjophthalmol-2020-316622 [pii]
AID - 10.1136/bjophthalmol-2020-316622 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2021 Jul;105(7):983-988. doi: 10.1136/bjophthalmol-2020-316622. 
      Epub 2020 Aug 21.