PMID- 32826640
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20230822
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 53
IP  - 2
DP  - 2021 Feb 1
TI  - Coingestion of Carbohydrate and Protein on Muscle Glycogen Synthesis after 
      Exercise: A Meta-analysis.
PG  - 384-393
LID - 10.1249/MSS.0000000000002476 [doi]
AB  - INTRODUCTION/PURPOSE: Evidence suggests that carbohydrate and protein (CHO-PRO) 
      ingestion after exercise enhances muscle glycogen repletion to a greater extent 
      than carbohydrate (CHO) alone. However, there is no consensus at this point, and 
      results across studies are mixed, which may be attributable to differences in 
      energy content and carbohydrate intake relative to body mass consumed after 
      exercise. The purpose of this study was determine the overall effects of CHO-PRO 
      and the independent effects of energy and relative carbohydrate content of 
      CHO-PRO supplementation on postexercise muscle glycogen synthesis compared with 
      CHO alone. METHODS: Meta-analysis was conducted on crossover studies assessing 
      the influence of CHO-PRO compared with CHO alone on postexercise muscle glycogen 
      synthesis. Studies were identified in a systematic review from PubMed and 
      Cochrane Library databases. Data are presented as effect size (95% confidence 
      interval [CI]) using Hedges' g. Subgroup analyses were conducted to evaluate 
      effects of isocaloric and nonisocaloric energy content and dichotomized by median 
      relative carbohydrate (high, >/=0.8 g.kg-1⋅h-1; low, <0.8 g.kg-1⋅h-1) content on 
      glycogen synthesis. RESULTS: Twenty studies were included in the analysis. 
      CHO-PRO had no overall effect on glycogen synthesis (0.13, 95% CI = -0.04 to 
      0.29) compared with CHO. Subgroup analysis found that CHO-PRO had a positive 
      effect (0.26, 95% CI = 0.04-0.49) on glycogen synthesis when the combined 
      intervention provided more energy than CHO. Glycogen synthesis was not 
      significant (-0.05, 95% CI = -0.23 to 0.13) in CHO-PRO compared with CON when 
      matched for energy content. There was no statistical difference of CHO-PRO on 
      glycogen synthesis in high (0.07, 95% CI = -0.11 to 0.22) or low (0.21, 95% CI = 
      -0.08 to 0.50) carbohydrate content compared with CHO. CONCLUSION: Glycogen 
      synthesis rates are enhanced when CHO-PRO are coingested after exercise compared 
      with CHO only when the added energy of protein is consumed in addition to, not in 
      place of, carbohydrate.
CI  - Copyright (c) 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the American College of Sports Medicine.
FAU - Margolis, Lee M
AU  - Margolis LM
AD  - Military Nutrition Division, U.S. Army Research Institute of Environmental 
      Medicine, Natick, MA.
FAU - Allen, Jillian T
AU  - Allen JT
FAU - Hatch-McChesney, Adrienne
AU  - Hatch-McChesney A
AD  - Military Nutrition Division, U.S. Army Research Institute of Environmental 
      Medicine, Natick, MA.
FAU - Pasiakos, Stefan M
AU  - Pasiakos SM
AD  - Military Nutrition Division, U.S. Army Research Institute of Environmental 
      Medicine, Natick, MA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Proteins/*administration & dosage
MH  - Exercise/*physiology
MH  - Glycogen/*biosynthesis
MH  - Humans
MH  - Muscle, Skeletal/*metabolism
PMC - PMC7803445
EDAT- 2020/08/23 06:00
MHDA- 2021/06/04 06:00
PMCR- 2021/01/12
CRDT- 2020/08/23 06:00
PHST- 2020/08/23 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
PHST- 2020/08/23 06:00 [entrez]
PHST- 2021/01/12 00:00 [pmc-release]
AID - 00005768-202102000-00016 [pii]
AID - MSS51811 [pii]
AID - 10.1249/MSS.0000000000002476 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2021 Feb 1;53(2):384-393. doi: 
      10.1249/MSS.0000000000002476.