PMID- 32827271
OWN - NLM
STAT- MEDLINE
DCOM- 20211001
LR  - 20211001
IS  - 1572-8781 (Electronic)
IS  - 1387-2176 (Linking)
VI  - 22
IP  - 3
DP  - 2020 Aug 22
TI  - Totally transparent hydrogel-based subdural electrode with patterned salt bridge.
PG  - 57
LID - 10.1007/s10544-020-00517-0 [doi]
AB  - A totally transparent subdural electrode was developed by embedding a conductive 
      poly (vinyl alcohol) (PVA)-filled microchannel made of poly(dimethylsiloxane) 
      (PDMS) into an another PVA hydrogel substrate. Tight bonding between the PVA 
      substrate and the PDMS microchannel (salt bridge) was achieved by mechanical 
      interlocking utilizing the microprotrusions formed on the microchannel. This 
      simple method of bonding without the use of any additives such as silane 
      molecules or nanofibers is very suitable for constructing biomedical devices. The 
      salt bridge electrode (total thickness, ca. 1.5 mm) was sufficiently soft, and 
      showed superior shape conformability that makes it an excellent choice as a 
      subdural electrode used on the brain surface. In vivo measurement proved that the 
      salt bridge electrode makes close contact to the exposed porcine brain and can 
      record brain wave signals of frequencies 1 ~ 15 Hz. In addition, the high 
      transparency of the electrode provided a clear view of the brain surface that 
      would assist the effective surgical operation and optogenetic research.
FAU - Nishimura, Ayaka
AU  - Nishimura A
AD  - Department of Biomedical Engineering, Graduate School of Biomedical Engineering, 
      Tohoku University, 6-6-04 Aoba-ku, Sendai, 980-8579, Japan.
FAU - Suwabe, Ryota
AU  - Suwabe R
AD  - Department of Finemechanics, Graduate School of Engineering, Tohoku University, 
      6-6-01 Aramaki, Aoba-ku, Sendai, 980-8579, Japan.
FAU - Ogihara, Yuka
AU  - Ogihara Y
AD  - Department of Finemechanics, Graduate School of Engineering, Tohoku University, 
      6-6-01 Aramaki, Aoba-ku, Sendai, 980-8579, Japan.
FAU - Yoshida, Shotaro
AU  - Yoshida S
AD  - Department of Finemechanics, Graduate School of Engineering, Tohoku University, 
      6-6-01 Aramaki, Aoba-ku, Sendai, 980-8579, Japan.
FAU - Abe, Hiroya
AU  - Abe H
AD  - Department of Finemechanics, Graduate School of Engineering, Tohoku University, 
      6-6-01 Aramaki, Aoba-ku, Sendai, 980-8579, Japan.
FAU - Osawa, Shin-Ichiro
AU  - Osawa SI
AD  - Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 2-1 
      Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
FAU - Nakagawa, Atsuhiro
AU  - Nakagawa A
AD  - Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 2-1 
      Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
AD  - Division for the Establishment of Frontier Sciences of the Organization for 
      Advanced Studies, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, 980-8577, 
      Japan.
FAU - Tominaga, Teiji
AU  - Tominaga T
AD  - Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 2-1 
      Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
FAU - Nishizawa, Matsuhiko
AU  - Nishizawa M
AUID- ORCID: 0000-0002-9423-0952
AD  - Department of Biomedical Engineering, Graduate School of Biomedical Engineering, 
      Tohoku University, 6-6-04 Aoba-ku, Sendai, 980-8579, Japan. 
      nishizawa@biomems.mech.tohoku.ac.jp.
AD  - Department of Finemechanics, Graduate School of Engineering, Tohoku University, 
      6-6-01 Aramaki, Aoba-ku, Sendai, 980-8579, Japan. 
      nishizawa@biomems.mech.tohoku.ac.jp.
AD  - Division for the Establishment of Frontier Sciences of the Organization for 
      Advanced Studies, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, 980-8577, 
      Japan. nishizawa@biomems.mech.tohoku.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200822
PL  - United States
TA  - Biomed Microdevices
JT  - Biomedical microdevices
JID - 100887374
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Hydrogels)
RN  - 63148-62-9 (baysilon)
RN  - 9002-89-5 (Polyvinyl Alcohol)
SB  - IM
MH  - Dimethylpolysiloxanes/chemistry
MH  - Electrodes
MH  - Hydrogels/*chemistry
MH  - Nanofibers/chemistry
MH  - Optical Phenomena
MH  - Polyvinyl Alcohol/chemistry
OTO - NOTNLM
OT  - Brain wave measurement
OT  - Hydrogel
OT  - Ionic circuit
OT  - Salt bridge
OT  - Subdural electrode
EDAT- 2020/08/23 06:00
MHDA- 2021/10/02 06:00
CRDT- 2020/08/23 06:00
PHST- 2020/08/23 06:00 [entrez]
PHST- 2020/08/23 06:00 [pubmed]
PHST- 2021/10/02 06:00 [medline]
AID - 10.1007/s10544-020-00517-0 [pii]
AID - 10.1007/s10544-020-00517-0 [doi]
PST - epublish
SO  - Biomed Microdevices. 2020 Aug 22;22(3):57. doi: 10.1007/s10544-020-00517-0.