PMID- 32828938
OWN - NLM
STAT- MEDLINE
DCOM- 20210712
LR  - 20210712
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 248
DP  - 2020 Sep
TI  - Efficacy of two porcine reproductive and respiratory syndrome (PRRS) 
      modified-live virus (MLV) vaccines against heterologous NADC30-like PRRS virus 
      challenge.
PG  - 108805
LID - S0378-1135(20)30943-3 [pii]
LID - 10.1016/j.vetmic.2020.108805 [doi]
AB  - The emergence of novel and variant porcine reproductive and respiratory syndrome 
      virus (PRRSV) strains has made controlling this disease a challenge in China. 
      Several NADC30-like PRRSV outbreaks have occurred in mainland China since 2013. 
      The objective of the present study was to evaluate the cross-protection efficacy 
      of two commercial PRRS modified-live virus (MLV) vaccines, derived from classical 
      PRRSV (VR2332) and highly pathogenic (HP) PRRSV (TJM-F92), against an 
      increasingly circulating NADC30-like lineage in pigs. Thirty-five PRRSV- and 
      antibody-free pigs were randomly divided into the following four groups: strict 
      control (SC), negative control (NC), Boehringer control (BC), and Zoetis control 
      (ZC) groups. The NADC30-like PRRSV used in this study caused fever, clinical 
      respiratory signs, and gross and microscopic lung lesions in inoculated pigs in 
      the NC group. Vaccination with the VR2332 vaccine significantly reduced the 
      percentage of viremic pigs as well as gross lung lesions and improved average 
      daily weight gain compared to the ZC and NC groups, suggesting that this MLV 
      vaccine provides cross-protection against the NADC30-like virus. There were no 
      significant differences in the efficacy of the two MLV vaccines based on clinical 
      scores, immunological responses, or pathological outcomes. This study 
      demonstrated that VR2332 MLV was effective against circulating NADC30-like PRRSV 
      and could be used to control NADC30-like virus infections in the field.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Chai, Weidong
AU  - Chai W
AD  - Boehringer Ingelheim Animal Health (Shanghai) Co. Ltd., Shanghai 200040, China.
FAU - Liu, Zhicheng
AU  - Liu Z
AD  - Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 
      510640, China.
FAU - Sun, Zhi
AU  - Sun Z
AD  - Asian Veterinary Research and Development Center, Boehringer Ingelheim (China) 
      Investment Co., Ltd., Pudong District, Shanghai, 201203, China.
FAU - Su, Liangke
AU  - Su L
AD  - Boehringer Ingelheim Animal Health (Shanghai) Co. Ltd., Shanghai 200040, China.
FAU - Zhang, Chunhong
AU  - Zhang C
AD  - Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 
      510640, China.
FAU - Huang, Lv
AU  - Huang L
AD  - Boehringer Ingelheim Animal Health (Shanghai) Co. Ltd., Shanghai 200040, China. 
      Electronic address: Lv.huang@boehringer-ingelheim.com.
LA  - eng
PT  - Journal Article
DEP - 20200805
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/*blood
MH  - *Cross Protection
MH  - Phylogeny
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus
MH  - Swine
MH  - Swine Diseases/immunology/*prevention & control
MH  - Vaccination
MH  - Vaccines, Attenuated/immunology
MH  - Viral Vaccines/*immunology
MH  - Viremia/prevention & control
MH  - Virulence
OTO - NOTNLM
OT  - Cross-protection
OT  - NADC30-like strain
OT  - Porcine reproductive and respiratory syndrome virus (PRRSV)
EDAT- 2020/08/24 06:00
MHDA- 2021/07/13 06:00
CRDT- 2020/08/24 06:00
PHST- 2020/05/06 00:00 [received]
PHST- 2020/06/13 00:00 [accepted]
PHST- 2020/08/24 06:00 [pubmed]
PHST- 2021/07/13 06:00 [medline]
PHST- 2020/08/24 06:00 [entrez]
AID - S0378-1135(20)30943-3 [pii]
AID - 10.1016/j.vetmic.2020.108805 [doi]
PST - ppublish
SO  - Vet Microbiol. 2020 Sep;248:108805. doi: 10.1016/j.vetmic.2020.108805. Epub 2020 
      Aug 5.