PMID- 32828975
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 589
DP  - 2020 Nov 15
TI  - Improving drug delivery performance of pH-triggered prodrug nanoparticles with an 
      adaptive polycation block as pH-sensitive gatekeeper.
PG  - 119796
LID - S0378-5173(20)30781-X [pii]
LID - 10.1016/j.ijpharm.2020.119796 [doi]
AB  - Efficient approach was established to improve the drug delivery performance of 
      the pH-triggered prodrug nanoparticles by introducing a polycation block as a 
      pH-sensitive gatekeeper. With the help of the poly(2-(diisopropylamino)ethyl 
      methacrylate) (PDPA) block as a pH-sensitive shell gatekeeper, the proposed 
      core-shell-corona PEG(43)-b-PDPA(65)-b-PFPMA(36)-DOX nanoparticles possessed a 
      higher drug release rate in the simulated acidic tumor intracellular 
      micro-environment while a lower premature drug leakage in the simulated weak 
      basic normal physiological medium, compared with the core-shell 
      PEG(43)-b-PFPMA(36)-DOX nanoparticles. The proposed strategy is expected to 
      design high-performance drug delivery systems (DDSs) for tumor treatment, with 
      improved anticancer efficacy but minimized toxic side effects.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Dong, Yuman
AU  - Dong Y
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China.
FAU - Liu, Peng
AU  - Liu P
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China. Electronic address: pliu@lzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200820
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Polyelectrolytes)
RN  - 0 (Prodrugs)
RN  - 0 (polycations)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Doxorubicin
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - Hydrogen-Ion Concentration
MH  - *Nanoparticles
MH  - Polyelectrolytes
MH  - *Prodrugs
OTO - NOTNLM
OT  - Core-shell-corona nanoparticles
OT  - Polycation shell gatekeeper
OT  - Polymer prodrug
OT  - Tumor chemotherapy
OT  - pH-Triggered release
EDAT- 2020/08/24 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/08/24 06:00
PHST- 2020/07/05 00:00 [received]
PHST- 2020/08/17 00:00 [revised]
PHST- 2020/08/18 00:00 [accepted]
PHST- 2020/08/24 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/08/24 06:00 [entrez]
AID - S0378-5173(20)30781-X [pii]
AID - 10.1016/j.ijpharm.2020.119796 [doi]
PST - ppublish
SO  - Int J Pharm. 2020 Nov 15;589:119796. doi: 10.1016/j.ijpharm.2020.119796. Epub 
      2020 Aug 20.