PMID- 3282972
OWN - NLM
STAT- MEDLINE
DCOM- 19880602
LR  - 20190814
IS  - 0016-6480 (Print)
IS  - 0016-6480 (Linking)
VI  - 69
IP  - 1
DP  - 1988 Jan
TI  - Enhancement of water intake by captopril (SQ14225), an angiotensin I-converting 
      enzyme inhibitor, in the goldfish, Carassius auratus.
PG  - 114-8
AB  - Single intraperitoneal (ip) injections of angiotension II (ANG II) stimulated 
      water intake for 60 min in a dose-related manner in the goldfish, Carassius 
      auratus. Single ip injections of captopril (SQ14225), an angiotension 
      I-converting enzyme (ACE) inhibitor, at lower doses (0.4 and 4.0 
      micrograms/fish), stimulated water intake for 60 min. This stimulation cannot be 
      ascribed to an increase in levels of plasma ANG I, since ANG I (2.2 
      micrograms/fish) did not stimulate drinking in the presence of SQ14225 (two 
      injections of 9.9 micrograms/fish). It is suggested that the elevated plasma ANG 
      I concentration achieved after blockade of ACE was converted into ANG II 
      approximately 50 min after SQ14225 injections (4.0 g/fish), when the injected 
      SQ14225 was effectively metabolized. Thus, the newly elevated level of ANG II may 
      have been responsible for the vigorous drinking. Higher doses of SQ14225 (40 and 
      200 microgram/fish) did not affect the water intake for 60 min, indicating that 
      the rate of basal water intake is independent of the renin-angiotensin system in 
      the goldfish.
FAU - Okawara, Y
AU  - Okawara Y
AD  - Department of Biology, Faculty of Science, Toho University, Chiba, Japan.
FAU - Kobayashi, H
AU  - Kobayashi H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 11128-99-7 (Angiotensin II)
RN  - 9041-90-1 (Angiotensin I)
RN  - 9G64RSX1XD (Captopril)
SB  - IM
MH  - Angiotensin I/pharmacology
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Captopril/*pharmacology
MH  - Cyprinidae/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Drinking Behavior/*drug effects
MH  - Female
MH  - Goldfish/*physiology
MH  - Male
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1016/0016-6480(88)90059-7 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 1988 Jan;69(1):114-8. doi: 10.1016/0016-6480(88)90059-7.