PMID- 32830177
OWN - NLM
STAT- MEDLINE
DCOM- 20210414
LR  - 20210414
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 60
IP  - 1
DP  - 2021 Jan 1
TI  - Anti-MuSK Positive Myasthenia Gravis with Anti-Lrp4 and Anti-titin Antibodies.
PG  - 137-140
LID - 10.2169/internalmedicine.4957-20 [doi]
AB  - In addition to muscle nicotinic acetylcholine receptor (AChR) and muscle-specific 
      kinase (MuSK), low-density lipoprotein receptor (Lrp4) has recently been 
      discovered to be a novel target antigen among patients with seronegative 
      myasthenia gravis (MG). We herein report the findings of a 62-year-old patient 
      who showed positivity for anti-MuSK, anti-Lrp4, and anti-titin antibodies. The 
      patient developed MG crisis following a 10-year history of intermittent double 
      vision with ptosis, and a 7-year history of dropped head. Our detailed clinical, 
      laboratory, and therapeutic descriptions highlight its unique characteristics of 
      anti-MuSK-antibody positive MG accompanied by anti-Lrp4 and anti-titin 
      antibodies.
FAU - Yamashita, Rika
AU  - Yamashita R
AD  - Department of Neurology, Osaka University Hospital, Japan.
FAU - Shimizu, Mikito
AU  - Shimizu M
AD  - Department of Neurology, Osaka University Hospital, Japan.
FAU - Baba, Kousuke
AU  - Baba K
AD  - Department of Neurology, Osaka University Hospital, Japan.
FAU - Beck, Goichi
AU  - Beck G
AD  - Department of Neurology, Osaka University Hospital, Japan.
FAU - Kinoshita, Makoto
AU  - Kinoshita M
AD  - Department of Neurology, Osaka University Hospital, Japan.
FAU - Okuno, Tatsusada
AU  - Okuno T
AD  - Department of Neurology, Osaka University Hospital, Japan.
FAU - Higuchi, Osamu
AU  - Higuchi O
AD  - Department of Clinical Research, Nagasaki Kawatana Medical Center, Japan.
FAU - Mochizuki, Hideki
AU  - Mochizuki H
AD  - Department of Neurology, Osaka University Hospital, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20200822
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Autoantibodies)
RN  - 0 (Connectin)
RN  - 0 (LDL-Receptor Related Proteins)
RN  - 0 (Receptors, LDL)
RN  - 0 (Receptors, Nicotinic)
SB  - IM
MH  - Autoantibodies
MH  - Connectin
MH  - Humans
MH  - LDL-Receptor Related Proteins
MH  - Middle Aged
MH  - *Myasthenia Gravis/drug therapy
MH  - Receptors, LDL
MH  - *Receptors, Nicotinic
PMC - PMC7835456
OTO - NOTNLM
OT  - anti-Lrp4 antibody
OT  - anti-MuSK antibody
OT  - anti-titin antibody
OT  - myasthenia gravis
OT  - steroid pulse therapy
COIS- The authors state that they have no Conflict of Interest (COI).
EDAT- 2020/08/25 06:00
MHDA- 2021/04/15 06:00
PMCR- 2021/01/01
CRDT- 2020/08/25 06:00
PHST- 2020/08/25 06:00 [pubmed]
PHST- 2021/04/15 06:00 [medline]
PHST- 2020/08/25 06:00 [entrez]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.2169/internalmedicine.4957-20 [doi]
PST - ppublish
SO  - Intern Med. 2021 Jan 1;60(1):137-140. doi: 10.2169/internalmedicine.4957-20. Epub 
      2020 Aug 22.