PMID- 32830817
OWN - NLM
STAT- MEDLINE
DCOM- 20210823
LR  - 20210823
IS  - 1842-1121 (Electronic)
IS  - 1841-8724 (Linking)
VI  - 29
IP  - 3
DP  - 2020 Sep 9
TI  - Non-alcoholic Steatohepatitis: Comparison of Intestinal Microbiota between 
      Different Metabolic Profiles. A Pilot Study.
PG  - 369-376
LID - 10.15403/jgld-497 [doi]
AB  - BACKGROUND AND AIMS: Non-alcoholic steatohepatitis (NASH) has multifactorial 
      etiopathogenesis, and intestinal microbiota is co-responsible in this process. 
      The aim of this study was to evaluate the intestinal microbiota in NASH patients 
      with different metabolic profiles. METHODS: Patients with biopsy-proven NASH were 
      evaluated. Subjects were divided into two groups according to their metabolic 
      profile, with or without metabolic syndrome (MS). Their characteristics in 
      relation to liver disease and intestinal microbiota were analyzed. To evaluate 
      the microbiota, breath tests to investigate small intestinal bacterial overgrowth 
      (SIBO) and fecal microbiota analysis by fluorescence in situ hybridization (FISH) 
      were performed. RESULTS: There was a high prevalence of SIBO in both groups, with 
      no significant difference between them. Breathing tests were positive in 43.8% of 
      patients with MS and 50% of those without MS. There was a significant difference 
      regarding the quantification of Verrucomicrobiales, less abundant in patients 
      with NASH without MS. Its lower concentration also correlated with higher serum 
      ferritin levels and higher hepatocyte ballooning. This order of bacteria, through 
      its representative in human microbiota, Akkermansia muciniphila, is associated 
      with mucosal protection and metabolic processes with liver aggression. 
      CONCLUSIONS: Our results suggested that lower Verrucomicrobiales concentration is 
      associated with higher inflammatory activity in patients with NASH without MS, 
      where the disease etiopathogenesis does not have its classic metabolic substrate.
FAU - De Oliveira, Juliano Machado
AU  - De Oliveira JM
AD  - University Hospital and School of Medicine, Federal University of Juiz de Fora, 
      Brazil. juliano.m.oliveira@gmail.com.
FAU - Pace, Fabio Lima
AU  - Pace FL
AD  - University Hospital and School of Medicine, Federal University of Juiz de Fora, 
      Brazil. fabiohlpace@gmail.com.
FAU - Ghetti, Fabiana De Faria
AU  - Ghetti FF
AD  - University Hospital and School of Medicine, Federal University of Juiz de Fora, 
      Brazil. bia.ghetti@hotmail.com.
FAU - Barbosa, Katia Valeria Bastos Dias
AU  - Barbosa KVBD
AD  - University Hospital and School of Medicine, Federal University of Juiz de Fora, 
      Brazil. katiavbarb@gmail.com.
FAU - Cesar, Dioneia Evangelista
AU  - Cesar DE
AD  - Biology Department, Federal University of Juiz de Fora, Brazil. 
      dioneia.cesar@gmail.com.
FAU - Chebli, Julio Maria Fonseca
AU  - Chebli JMF
AD  - University Hospital and School of Medicine, Federal University of Juiz de Fora, 
      Brazil. chebli@globo.com.
FAU - Ferreira, Lincoln Eduardo Villela Vieira de Castro
AU  - Ferreira LEVVC
AD  - University Hospital and School of Medicine, Federal University of Juiz de Fora, 
      Brazil. lincoln@gedcenter.com.br.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20200909
PL  - Romania
TA  - J Gastrointestin Liver Dis
JT  - Journal of gastrointestinal and liver diseases : JGLD
JID - 101272825
SB  - IM
MH  - Adult
MH  - Bacteria/*growth & development
MH  - Cross-Sectional Studies
MH  - Dysbiosis
MH  - Feces/microbiology
MH  - Female
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - Intestines/*microbiology
MH  - Male
MH  - Metabolic Syndrome/diagnosis/*microbiology
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/diagnosis/*microbiology
MH  - Pilot Projects
EDAT- 2020/08/25 06:00
MHDA- 2021/08/24 06:00
CRDT- 2020/08/25 06:00
PHST- 2020/08/25 06:00 [pubmed]
PHST- 2021/08/24 06:00 [medline]
PHST- 2020/08/25 06:00 [entrez]
AID - 10.15403/jgld-497 [doi]
PST - epublish
SO  - J Gastrointestin Liver Dis. 2020 Sep 9;29(3):369-376. doi: 10.15403/jgld-497.