PMID- 32831950
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 1831-4732 (Electronic)
IS  - 1831-4732 (Linking)
VI  - 18
IP  - 8
DP  - 2020 Aug
TI  - Review of the existing maximum residue levels for propineb according to Article 
      12 of Regulation (EC) No 396/2005.
PG  - e06233
LID - 10.2903/j.efsa.2020.6233 [doi]
LID - e06233
AB  - According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the 
      maximum residue levels (MRLs) currently established at European level for the 
      pesticide active substance propineb. Although this active substance is no longer 
      authorised within the EU, due to insufficient information in order to conclude on 
      the consumer risk assessment for the active substance, the toxicity of the 
      metabolite propane-1,2-diamine (PDA) the impact on non-target organisms and the 
      risk to honeybees, MRLs based on the use of propineb were established by the 
      Codex Alimentarius Commission (codex maximum residue limits; CXLs) and are still 
      in place. Additionally, propineb has potential endocrine-disrupting properties 
      related to the hazards of its major metabolite 4-methylimidazolidine-2-thione 
      (PTU). Lacking a full toxicological characterisation for the compound PDA, 
      exposure data for metabolites propineb-DIDT in plants and PDA in processed 
      commodities and considering that propineb-MRLs correlated to CXLs were based on 
      EU uses that were withdrawn following the non-renewal and are no longer in place, 
      it was not possible for EFSA to perform an assessment of these MRLs and their 
      incorporation in European legislation cannot be recommended. Nevertheless, 
      available data allowed EFSA to propose a marker residue and a limit of 
      quantification (LOQ) for enforcement against potential illegal uses.
CI  - (c) 2020 European Food Safety Authority. EFSA Journal published by John Wiley and 
      Sons Ltd on behalf of European Food Safety Authority.
CN  - European Food Safety Authority (EFSA)
FAU - Anastassiadou, Maria
AU  - Anastassiadou M
FAU - Bernasconi, Giovanni
AU  - Bernasconi G
FAU - Brancato, Alba
AU  - Brancato A
FAU - Carrasco Cabrera, Luis
AU  - Carrasco Cabrera L
FAU - Ferreira, Lucien
AU  - Ferreira L
FAU - Greco, Luna
AU  - Greco L
FAU - Jarrah, Samira
AU  - Jarrah S
FAU - Kazocina, Aija
AU  - Kazocina A
FAU - Leuschner, Renata
AU  - Leuschner R
FAU - Magrans, Jose Oriol
AU  - Magrans JO
FAU - Miron, Ileana
AU  - Miron I
FAU - Nave, Stefanie
AU  - Nave S
FAU - Pedersen, Ragnor
AU  - Pedersen R
FAU - Reich, Hermine
AU  - Reich H
FAU - Rojas, Alejandro
AU  - Rojas A
FAU - Sacchi, Angela
AU  - Sacchi A
FAU - Santos, Miguel
AU  - Santos M
FAU - Theobald, Anne
AU  - Theobald A
FAU - Vagenende, Benedicte
AU  - Vagenende B
FAU - Verani, Alessia
AU  - Verani A
LA  - eng
PT  - Journal Article
DEP - 20200818
PL  - United States
TA  - EFSA J
JT  - EFSA journal. European Food Safety Authority
JID - 101642076
PMC - PMC7433000
OTO - NOTNLM
OT  - CXL
OT  - MRL review
OT  - Regulation (EC) No 396/2005
OT  - consumer risk assessment
OT  - pesticide
OT  - propineb
EDAT- 2020/08/25 06:00
MHDA- 2020/08/25 06:01
PMCR- 2020/08/18
CRDT- 2020/08/25 06:00
PHST- 2020/08/25 06:00 [entrez]
PHST- 2020/08/25 06:00 [pubmed]
PHST- 2020/08/25 06:01 [medline]
PHST- 2020/08/18 00:00 [pmc-release]
AID - EFS26233 [pii]
AID - 10.2903/j.efsa.2020.6233 [doi]
PST - epublish
SO  - EFSA J. 2020 Aug 18;18(8):e06233. doi: 10.2903/j.efsa.2020.6233. eCollection 2020 
      Aug.