PMID- 32832269
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 8
DP  - 2020
TI  - Gut microbiota of obese and diabetic Thai subjects and interplay with dietary 
      habits and blood profiles.
PG  - e9622
LID - 10.7717/peerj.9622 [doi]
LID - e9622
AB  - Obesity and type 2 diabetes mellitus (T2DM) have become major public health 
      issues globally. Recent research indicates that intestinal microbiota play roles 
      in metabolic disorders. Though there are numerous studies focusing on gut 
      microbiota of health and obesity states, those are primarily focused on Western 
      countries. Comparatively, only a few investigations exist on gut microbiota of 
      people from Asian countries. In this study, the fecal microbiota of 30 adult 
      volunteers living in Chiang Rai Province, Thailand were examined using 
      next-generation sequencing (NGS) in association with blood profiles and dietary 
      habits. Subjects were categorized by body mass index (BMI) and health status as 
      follows; lean (L) = 8, overweight (OV) = 8, obese (OB) = 7 and diagnosed T2DM = 
      7. Members of T2DM group showed differences in dietary consumption and fasting 
      glucose level compared to BMI groups. A low level of high-density cholesterol 
      (HDL) was observed in the OB group. Principal coordinate analysis (PCoA) revealed 
      that microbial communities of T2DM subjects were clearly distinct from those of 
      OB. An analogous pattern was additionally illustrated by multiple factor analysis 
      (MFA) based on dietary habits, blood profiles, and fecal gut microbiota in BMI 
      and T2DM groups. In all four groups, Bacteroidetes and Firmicutes were the 
      predominant phyla. Abundance of Faecalibacterium prausnitzii, a 
      butyrate-producing bacterium, was significantly higher in OB than that in other 
      groups. This study is the first to examine the gut microbiota of adult Thais in 
      association with dietary intake and blood profiles and will provide the platform 
      for future investigations.
CI  - (c) 2020 Gruneck et al.
FAU - Gruneck, Lucsame
AU  - Gruneck L
AD  - School of Science, Mae Fah Luang University, Muang, Chiang Rai, Thailand.
AD  - Gut Microbiome Research Group, Mae Fah Luang University, Muang, Chiang Rai, 
      Thailand.
FAU - Kullawong, Niwed
AU  - Kullawong N
AD  - Gut Microbiome Research Group, Mae Fah Luang University, Muang, Chiang Rai, 
      Thailand.
AD  - School of Health Science, Mae Fah Luang University, Muang, Chiang Rai, Thailand.
FAU - Kespechara, Kongkiat
AU  - Kespechara K
AD  - Sooksatharana (Social Enterprise) Co., Ltd., Muang, Phuket, Thailand.
FAU - Popluechai, Siam
AU  - Popluechai S
AD  - School of Science, Mae Fah Luang University, Muang, Chiang Rai, Thailand.
AD  - Gut Microbiome Research Group, Mae Fah Luang University, Muang, Chiang Rai, 
      Thailand.
LA  - eng
PT  - Journal Article
DEP - 20200803
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC7409811
OTO - NOTNLM
OT  - BMI
OT  - Fecal gut microbiota
OT  - Next-generation sequencing
OT  - Obesity
OT  - Thailand
OT  - Type 2 diabetes mellitus
COIS- Kongkiat Kespechara is the president of Sooksatharana (Social Enterprise) Co., 
      Ltd, Thailand.
EDAT- 2020/08/25 06:00
MHDA- 2020/08/25 06:01
PMCR- 2020/08/03
CRDT- 2020/08/25 06:00
PHST- 2020/03/12 00:00 [received]
PHST- 2020/07/07 00:00 [accepted]
PHST- 2020/08/25 06:00 [entrez]
PHST- 2020/08/25 06:00 [pubmed]
PHST- 2020/08/25 06:01 [medline]
PHST- 2020/08/03 00:00 [pmc-release]
AID - 9622 [pii]
AID - 10.7717/peerj.9622 [doi]
PST - epublish
SO  - PeerJ. 2020 Aug 3;8:e9622. doi: 10.7717/peerj.9622. eCollection 2020.