PMID- 32835086
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 2352-9393 (Print)
IS  - 2352-9393 (Electronic)
IS  - 2352-9393 (Linking)
VI  - 33
DP  - 2020 Oct
TI  - Effect of oral l-Glutamine supplementation on Covid-19 treatment.
PG  - 24-31
LID - 10.1016/j.yclnex.2020.07.003 [doi]
AB  - OBJECTIVES: The aim of this study is to investigate the effect of oral 
      l-Glutamine supplementation on hospitalization time, need for intensive care unit 
      and Coronavirus Disease-19 (Covid-19) mortality. METHODS: The study included 30 
      Covid-19 patients using l-Glutamine and 30 Covid-19 patients who did not use 
      l-Glutamine with similar age, gender and clinical status. Diagnostic tests, 
      laboratory examinations, clinical findings and computed thorax tomography imaging 
      of the patients were evaluated. RESULTS: Hospitalization time was 10.4 +/- 1.9 days 
      in Covid-19 without L-Glutamine group and 8.9 +/- 1.8 days in Covid-19 with 
      L-Glutamine group (p = 0.005). In Covid-19 without the L-Glutamine group, four 
      patients require the ICU though no one in the other group required that (p = 
      0.038). Only one mortality was observed in Covid-19 without the L-Glutamine group 
      (p = 0.999). CONCLUSIONS: Nutritional supplements such as L-Glutamine boost 
      immune system especially by inhibition of inflammatory responses. Our results 
      suggest adding enteral L-glutamine to the normal nutrition in the early period of 
      Covid-19 infection may lead to a shortened hospital stay and lead to less need 
      for ICU. Larger-scale studies are needed to evaluate the effect of adding enteral 
      L-Glutamine to the currently used treatments in the infectious diseases 
      especially like Covid-19.
CI  - (c) 2020 The Authors.
FAU - Cengiz, Mahir
AU  - Cengiz M
FAU - Borku Uysal, Betul
AU  - Borku Uysal B
FAU - Ikitimur, Hande
AU  - Ikitimur H
FAU - Ozcan, Erkan
AU  - Ozcan E
FAU - Islamoglu, Mehmet Sami
AU  - Islamoglu MS
FAU - Aktepe, Emre
AU  - Aktepe E
FAU - Yavuzer, Hakan
AU  - Yavuzer H
FAU - Yavuzer, Serap
AU  - Yavuzer S
LA  - eng
PT  - Journal Article
DEP - 20200729
PL  - England
TA  - Clin Nutr Exp
JT  - Clinical nutrition experimental
JID - 101705340
PMC - PMC7387270
OTO - NOTNLM
OT  - Covid-19
OT  - Nutrition
OT  - Pneumonia
OT  - SARS Cov-2
OT  - l-Glutamine
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/08/25 06:00
MHDA- 2020/08/25 06:01
PMCR- 2020/07/29
CRDT- 2020/08/25 06:00
PHST- 2020/05/29 00:00 [received]
PHST- 2020/07/21 00:00 [accepted]
PHST- 2020/08/25 06:00 [entrez]
PHST- 2020/08/25 06:00 [pubmed]
PHST- 2020/08/25 06:01 [medline]
PHST- 2020/07/29 00:00 [pmc-release]
AID - S2352-9393(20)30016-6 [pii]
AID - 10.1016/j.yclnex.2020.07.003 [doi]
PST - ppublish
SO  - Clin Nutr Exp. 2020 Oct;33:24-31. doi: 10.1016/j.yclnex.2020.07.003. Epub 2020 
      Jul 29.