PMID- 32835571
OWN - NLM
STAT- MEDLINE
DCOM- 20210701
LR  - 20210701
IS  - 1744-5205 (Electronic)
IS  - 0882-0538 (Linking)
VI  - 35
IP  - 4
DP  - 2020 May 18
TI  - Peripapillary Retinal Nerve Fiber Layer Changes in Patients with Diabetes 
      Mellitus: A Case-control Study.
PG  - 257-260
LID - 10.1080/08820538.2020.1810289 [doi]
AB  - PURPOSE: To evaluate peripapillary retinal nerve fiber layer (RNFL) changes in 
      patients with diabetes mellitus (DM) and compare them with those of normal 
      population. In addition, this study aims to determine potential factors, 
      affecting RNFL changes in patients with DM. METHODS: Participants in this study 
      were 107 patients (211 eyes) with DM and 100 healthy controls (200 eyes). 
      Diabetic patients were further classified into four groups depending on severity 
      of diabetic retinopathy (no retinopathy, mild, moderate, severe nonproliferative 
      diabetic retinopathy, and proliferative diabetic retinopathy, while presence of 
      macular edema was also assessed. All participants underwent spectral-domain 
      optical coherence tomography (SD-OCT) to measure RNFL thickness, while 
      demographic and clinical characteristics of the participants were also recorded. 
      RESULTS: Patients with DM with or without DR presented significantly decreased 
      peripapillary RNFL thickness in all quadrants. In the diabetic group, the 
      multivariate analysis showed a significant association between decreased average 
      RNFL thickness and increased HbA1c (p < 0.001), longer DM duration (p = 0.007), 
      and more severe diabetic retinopathy status (p = 0.016), while presence of DME, 
      age, gender, hypertension, and hyperlipidemia were not found to be associated 
      with RNFL thickness decrease. CONCLUSION: Diabetes mellitus seems to affect RNFL 
      thickness, suggesting that early neurodegenerative changes may occur, potentially 
      before microvascular alterations. Since duration of disease, DR severity, and 
      HbA1c levels were associated with RNFL thinning, modifying glycemic control seems 
      to be important to potentially prevent the development of DM complications.
FAU - Chatziralli, Irini
AU  - Chatziralli I
AD  - 2 Department of Ophthalmology, National and Kapodistrian University of Athens , 
      Athens, Greece.
FAU - Karamaounas, Aristotelis
AU  - Karamaounas A
AD  - 1 Department of Ophthalmology, National and Kapodistrian University of Athens , 
      Athens, Greece.
FAU - Dimitriou, Eleni
AU  - Dimitriou E
AD  - 2 Department of Ophthalmology, National and Kapodistrian University of Athens , 
      Athens, Greece.
FAU - Kazantzis, Dimitrios
AU  - Kazantzis D
AD  - 2 Department of Ophthalmology, National and Kapodistrian University of Athens , 
      Athens, Greece.
FAU - Theodossiadis, George
AU  - Theodossiadis G
AD  - 2 Department of Ophthalmology, National and Kapodistrian University of Athens , 
      Athens, Greece.
FAU - Kozobolis, Vassilios
AU  - Kozobolis V
AD  - Eye Institute of Thrace, Democritus University of Thrace , Alexandroupolis, 
      Greece.
FAU - Theodossiadis, Panagiotis
AU  - Theodossiadis P
AD  - 2 Department of Ophthalmology, National and Kapodistrian University of Athens , 
      Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20200822
PL  - England
TA  - Semin Ophthalmol
JT  - Seminars in ophthalmology
JID - 8610759
SB  - IM
MH  - Aged
MH  - *Diabetes Mellitus
MH  - Diabetic Retinopathy/*diagnosis
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Nerve Fibers/pathology
MH  - Optic Disk/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
OTO - NOTNLM
OT  - HbA1c
OT  - RNFL
OT  - controls
OT  - diabetes
OT  - retinopathy
EDAT- 2020/08/25 06:00
MHDA- 2021/07/02 06:00
CRDT- 2020/08/25 06:00
PHST- 2020/08/25 06:00 [pubmed]
PHST- 2021/07/02 06:00 [medline]
PHST- 2020/08/25 06:00 [entrez]
AID - 10.1080/08820538.2020.1810289 [doi]
PST - ppublish
SO  - Semin Ophthalmol. 2020 May 18;35(4):257-260. doi: 10.1080/08820538.2020.1810289. 
      Epub 2020 Aug 22.